Author

M. Humphries

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

J. Askari· 2 shared A. Kalli· 1 shared A. Messent· 1 shared B. Lelli· 1 shared B. T. Goult· 1 shared B. Weigelin· 1 shared C. Jorgensen· 1 shared C. Souilhol· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCell Biology

J. Askari

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Author profile →

4 papers

Recent·Most cited

Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1

R. E. Gough, M. C. Jones, T. Zacharchenko, S. Le, M. Yu, G. Jacquemet, s. P. muench, J. Yan, J. D. Humphries, C. Jorgensen, M. Humphries, B. T. Goult

This study identifies a direct interaction between CDK1 and talin at integrin adhesions, showing CDK1 modulates talin's mechanosensitivity and affects downstream mechanotransduction.

bioRxiv · Mar 19, 2021Cell Biology

FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress

R. Choudhury, N. Bayatti, R. Scharff, E. Szula, V. Tilakaratna, M. S. Udsen, S. McHarg, J. Askari, M. Humphries, P. N. Bishop, S. J. Clark

This study shows FHL-1 protects RPE cells from oxidative stress via α5β1 integrin interaction, with increased heat-shock protein expression and improved cell survival.

bioRxiv · Sep 28, 2020 · PreprintCell Biology

Glycocalyx-mediated Cell Adhesion and Migration

S. Schmidt, B. Weigelin, J. te Riet, V. te Boekhorst, M. te Lindert, M. Wijers-Rouw, B. Lelli, L. Rognoni, M. Krause-Vortmeyer, A. Messent, L. Bracci, K. E. Gottschalk, S. Kissler, M. Humphries, D. J. Lefeber, , P. Friedl

This study shows the glycocalyx enables cell adhesion and amoeboid migration through nanoscale interactions and mechano-coupling, independent of integrin function.

bioRxiv · Jun 12, 2020 · PreprintCell Biology

β1 integrin is a sensor of blood flow direction

I. Xanthis, C. Souilhol, J. Serbanovic-Canic, H. Roddie, A. Kalli, M. Fragiadaki, R. Wong, D. Shah, J. Askari, L. Canham, N. Akhtar, S. Feng, V. Ridger, J. Waltho, E. Pinteaux, , P. Evans

This study identifies β1 integrin as a sensor for blood flow direction in endothelial cells, showing it is activated by unidirectional but not bidirectional shear stress.

bioRxiv · Jan 3, 2019Cell Biology