Author

S. Le

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 4 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:protein folding & dynamics· 2 Organism:C. elegans· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

J. Yan· 7 shared M. Yao· 3 shared W. Huang· 3 shared B. T. Goult· 2 shared M. Yu· 2 shared R. E. Gough· 2 shared A. Derrico· 1 shared A. Morrison-Porter· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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7 shared papersBiophysics

J. Yan

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

In-situ Single-Molecule Investigations of the Impacts of Biochemical Perturbations on Conformational Intermediates of Monomeric α-Synuclein

W. Huang, S. Le, M. Yao, Y. Shi, J. Yan

This study uses in-situ single-molecule techniques to identify a partially folded conformation of α-synuclein and shows its sensitivity to biochemical perturbations and drugs.

bioRxiv · Aug 31, 2023Biophysics

Mechanical regulation of Titin N2B-us conformation and its binding to FHL2

Y. SUN, W. HUANG, S. LE, J. Yan

The paper investigates the conformation of N2B-us and its force-dependent interaction with FHL2 using AlphaFold2 and single-molecule experiments, revealing a stable structural domain and mechanosensitive binding.

bioRxiv · Sep 5, 2022 · PreprintBiophysics

The mechanical stability of Tension Gauge Tethers

J. Liu, S. Le, M. Yao, W. Huang, Z. Tio, Y. Zhou, J. Yan

This study quantifies the tension-dependent lifetime of tension gauge tethers to better understand their mechanical stability under physiological stretching conditions and reinterprets previous experimental observations.

bioRxiv · Mar 11, 2022 · PreprintBiophysics

Mechano-Biochemical Regulation of the C. elegans HMP1-HMP2 protein complex

S. Le, M. Yu, S. Martin, J. Hardin, J. Yan

This study investigates how mechanical tension regulates the stability and function of the HMP1-HMP2 protein complex in C. elegans, revealing its role in mechanotransduction.

bioRxiv · Sep 27, 2021 · PreprintBiophysics

Force-dependent interactions between talin and full-length vinculin

Y. Wang, M. Yao, K. B. Baker, R. E. Gough, S. Le, B. T. Goult, J. Yan

This study investigates how mechanical forces affect talin-vinculin interactions, showing that force exposure of a vinculin binding site relieves vinculin autoinhibition and enhances binding affinity.

bioRxiv · Apr 26, 2021Biophysics

Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1

R. E. Gough, M. C. Jones, T. Zacharchenko, S. Le, M. Yu, G. Jacquemet, s. P. muench, J. Yan, J. D. Humphries, C. Jorgensen, M. Humphries, B. T. Goult

This study identifies a direct interaction between CDK1 and talin at integrin adhesions, showing CDK1 modulates talin's mechanosensitivity and affects downstream mechanotransduction.

bioRxiv · Mar 19, 2021Cell Biology

Elevated SARS-CoV-2 Antibodies Distinguish Severe Disease in Early COVID-19 Infection

N. S. Haddad, D. C. Nguyen, M. E. Kuruvilla, A. Morrison-Porter, F. Anam, K. S. Cashman, R. P. Ramonell, S. Kyu, A. S. Saini, M. Cabrera-Mora, A. Derrico, D. Alter, J. D. Roback, M. Horwath, J. B. O'Keefe, , F. E.-H. Lee

This paper develops a multiplex immunoassay to measure SARS-CoV-2 antibody responses and finds that severe COVID-19 is associated with higher early antibody levels against S1 and N proteins.

bioRxiv · Dec 4, 2020 · PreprintImmunology

Tension-dependent stretching and folding of ZO-1 controls the localization of its interactors

D. Spadaro, S. Le, T. Laroche, I. Mean, L. Jond, J. Yan, S. Citi

This study shows that ZO-1 undergoes tension-dependent stretching and folding, which regulates the localization of its interactors and affects epithelial homeostasis.

bioRxiv · Jun 27, 2017Cell Biology