Author

A. Saghatelian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 4 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. F. M. Pinto· 2 shared A. E. Sears· 1 shared A. M. Pinto· 1 shared A. M. Santos· 1 shared A. Manglik· 1 shared A. O. Souza· 1 shared A. Santoro· 1 shared B. B. Kahn· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersBiochemistry

A. F. M. Pinto

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Author profile →

6 papers

Recent·Most cited

Tissue-specific sex difference in the metabolism of fatty acid esters of hydroxy fatty acids

M. Riecan, V. Domanska, C. Lupu, M. Patel, M. Vondrackova, M. Rossmeisl, A. Saghatelian, F. Lupu, O. Kuda

This study examines sex differences in FAHFA metabolism across tissues in mice, finding higher FAHFA levels in females in specific adipose depots and lower Adtrp expression, suggesting sex-dependent regulation of FAHFA metabolism.

bioRxiv · Nov 15, 2023 · PreprintBiochemistry

Inflammation causes insulin resistance via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels

S. Yan, A. Santoro, M. J. Niphakis, A. M. Pinto, C. L. Jacobs, R. Ahmad, R. M. Suciu, B. R. Fonslow, R. B. Herbst-Graham, N. Ngo, C. L. Henry, D. M. Herbst, A. Saghatelian, B. B. Kahn, E. D. Rosen

This study identifies the IRF3/AIG1 axis in adipocytes as a mechanism linking obesity-induced inflammation to insulin resistance and suggests AIG1 inhibition as a therapeutic approach.

bioRxiv · Aug 8, 2023 · PreprintPhysiology

Proteomic discovery of chemical probes that perturb protein complexes in human cells

M. Lazear, J. Remsberg, M. Jaeger, K. Rothamel, H.-l. Her, K. DeMeester, E. Njomen, S. Hogg, J. Rahman, L. Whitby, S. J. Won, M. Schafroth, D. Ogasawara, M. Yokoyama, G. Lindsey, , B. Cravatt

This study develops a proteomic strategy to identify chemical probes that perturb protein complexes in human cells by analyzing electrophilic compounds' effects on protein interactions.

bioRxiv · Dec 12, 2022Biochemistry

Autoantibody and hormone activation of the thyrotropin G protein-coupled receptor

B. Faust, I. Singh, K. Zhang, N. Hoppe, A. F. M. Pinto, Y. Muftuoglu, C. B. Billesboelle, A. Saghatelian, Y. Cheng, A. Manglik

This study determines cryogenic-electron microscopy structures of active and inactive TSHR, revealing how autoantibodies and TSH activate the receptor through similar conformational changes.

bioRxiv · Jan 6, 2022 · PreprintBiochemistry

Dissecting lipid contents in the distinct regions of native retinal rod disk membranes

C. L. Sander, A. E. Sears, A. F. M. Pinto, E. H. Choi, S. L. Kahremany, H. G. Jin, S. Suh, E. Pardon, Z. Dong, J. Steyaert, A. Saghatelian, D. Skowronska-Krawczyk, P. D. Kiser, K. Palczewski

The paper analyzes lipid composition differences between center and rim regions of retinal rod disk membranes using co-immunopurification and lipidomic analysis.

bioRxiv · Jan 11, 2021Cell Biology

A novel role for Myosin-Va in mitochondrial fission

J. S. Araujo, R. M. P. Silva-Junior, T. Zhang, C. R. Schiavon, Q. Chu, M. Wu, C. L. S. Pontes, A. O. Souza, L. C. Alberici, A. M. Santos, S. B. Ingle, A. Saghatelian, J. Spudich, U. Manor, E. M. Espreafico

This paper shows myosin-Va facilitates mitochondrial fission in melanoma cells by interacting with Spire1C and localizing to fission sites, linking it to the Warburg effect.

bioRxiv · May 31, 2019 · PreprintCell Biology