C. Uetrecht

Glycan-induced structural activation softens the human papillomavirus capsid for entry through reduction of intercapsomere flexibility

This study investigates how glycan-induced structural activation of the HPV capsid facilitates entry by reducing intercapsomere flexibility.

The kinetics of SARS-CoV-2 nsp7-11 polyprotein processing and impact on complexation with nsp16

The paper quantifies the kinetics of SARS-CoV-2 polyprotein processing and its impact on RTC complex formation using native MS.

Structural Insights into the Interaction Between Adenovirus C5 Hexon and Human Lactoferrin

This study presents cryo-EM structures of HAdV-5C hexon and its complex with human lactoferrin, revealing molecular interactions critical for viral entry.

An RNA to rule them all: Critical steps in Lassa virus ribonucleoparticle assembly and recruitment

This study identifies RNA's role in disassembling NP trimers and forming RNA-bound assemblies, and shows Z protein interaction with NP is pH-dependent.

Mapping the peptide binding groove of MHC class I

The paper uses native mass spectrometry to analyze peptide binding to MHC class I and quantifies binding affinity, offering an alternative to computational tools for faster and more accurate predictions.

Dissociation of β2m from MHC Class I Triggers Formation of Noncovalent, Transient Heavy Chain Dimers

This study investigates the formation of non-covalent MHC-I heavy chain dimers after dissociation of β2m and peptide, revealing a dimerization interface mediated by the 3 domain.

Protein secondary structure affects glycan clustering in native mass spectrometry

The paper investigates how protein secondary structure affects glycan clustering in native mass spectrometry, finding that β-sheet content strongly influences clustering behavior.

Murine norovirus capsid plasticity - Glycochenodeoxycholic acid stabilizes P domain dimers and triggers escape from antibody recognition

This paper investigates how GCDCA stabilizes MNV P-domain dimers, leading to structural changes that enable immune escape by preventing antibody recognition.

N-terminal VP1 truncations favor T=1 norovirus-like particles

The paper identifies N-terminal VP1 truncations as a cause for T=1 norovirus-like particle formation and discusses implications for vaccine and biotechnological applications.

Glycan-induced protein dynamics in human norovirus P dimers depend on virus strain and deamidation status

This study uses HDX-MS to analyze glycan-induced structural dynamics in norovirus P dimers across strains and deamidation states, revealing strain- and deamidation-dependent changes in protein flexibility and solvent exposure.

Hallmarks of Alpha- and Betacoronavirus non-structural protein 7+8 complexes

This study determines the stoichiometry and topology of nsp7+8 complexes from seven coronaviruses using mass spectrometry and biophysical techniques, revealing three clustering groups with distinct assembly patterns.

Processing of the SARS-CoV pp1a/ab nsp7-10 region

The paper uses native mass spectrometry to analyze SARS-CoV polyprotein processing, revealing cleavage order and protein interactions in the nsp7-10 region.

Flagella methylation promotes bacterial adhesion and host cell invasion

This study shows that flagellin methylation in Salmonella enhances adhesion and invasion by increasing surface hydrophobicity, aiding gut colonization and host infection.

Molecular organization of soluble type III secretion system sorting platform complexes

The paper reconstitutes and characterizes the molecular structure of the Salmonella Typhimurium T3SS sorting platform, revealing its stoichiometry and L-shaped conformation.