Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
18 papers
Recent·Most cited
J. C. Van Loon, F. Le Mauff, M. Vargas, S. Gilbert, R. Pfoh, Z. A. Morrison, E. Razvi, M. Nitz, D. Sheppard, P. L. Howell
This study determines the structure of PelA and shows it modifies Pel through deacetylation and hydrolysis, with PelAB interaction enhancing deacetylation and guiding export.
bioRxiv · Jun 28, 2024Microbiology
D. Raju, S. A. Turner, K. Castro, G. B. Whitfield, D. LaMarche, S. Mahajan, R. Pfoh, F. Le Mauff, M. Joe, S. Sarkar, T. L. Lowary, D. C. Sheppard, D. J. Wozniak, M. G. Surette, P. L. Howell
This study identifies the Pel polysaccharide as a driver of autoaggregation in S. intermedius, linking it to biofilm formation and increased pathogenicity.
bioRxiv · Apr 20, 2024Microbiology
L. Heilg, F. Natasha, N. Trinks, V. K. AIMANIANDA BOPAIAH, S. Sze Wah Wong, T. Fontaine, U. Terpitz, L. Strobel, F. Le Mauff, D. Sheppard, S. Schaeuble, O. Kurzai, K. Huenniger, E. Weiss, M. Vargas, , J. Loeffler
This study identifies galactosaminogalactan as the fungal ligand for CD56 on human NK cells, triggering antifungal responses and immune cell activation.
bioRxiv · Aug 18, 2023 · PreprintMicrobiology
A. Eddenden, M. K. Dooda, Z. A. Morrison, A. S. Subramanian, P. L. Howell, J. M. Troutman, M. Nitz
This paper investigates the metabolic incorporation of GlcNAz into glycans in E. coli, finding it primarily in peptidoglycan with lower levels in PNAG and none in LPS or ECA.
bioRxiv · Aug 17, 2023Biochemistry
K. Low, A. A. Gheorghita, S. Tammam, G. B. Whitfield, Y. E. Li, L. M. Riley, J. Weadge, S. Caldwell, P. A. Chong, M. Walvoort, E. Kitova, J. Klassen, P. L. Howell
This study identifies AlgF as a protein-protein interaction mediator in Pseudomonas aeruginosa that facilitates the formation of an acetylation and export complex for alginate modification.
bioRxiv · Jul 25, 2023Microbiology
R. M. Kratofil, T. E. Randall, J. W. Hommes, R. Sejuty, J. Chisholm, D. Raju, M. Vargas, P. L. Howell, G. B. Pier, D. W. Morck, J. J. Harrison, P. Kubes
This study shows that disrupting the PNAG biofilm matrix with PgaB allows neutrophils to access and clear S. aureus biofilms in vivo.
bioRxiv · Jan 23, 2023 · PreprintImmunology
G. Melaugh, V. Martinez, P. Baker, P. J. Hill, P. L. Howell, D. J. Wozniak, R. J. Allen
This study identifies two distinct types of multicellular aggregates in Pseudomonas aeruginosa cultures, mediated by different factors in exponential vs stationary phase.
bioRxiv · May 18, 2022Microbiology
A. R. Fullen, J. L. Gutierrez-Ferman, K. S. Yount, C. F. Love, H. G. Choi, M. A. Vargas, D. Raju, K. N. Corps, P. L. Howell, P. Dubey, R. Deora
bioRxiv · Apr 6, 2022Microbiology
Z. Morrison, A. Eddenden, A. S. Subramanian, P. L. Howell, m. nitz
The paper identifies UDP-GlcNAc analogues that inhibit PNAG polymerization and biofilm formation in E. coli by terminating PNAG chains.
bioRxiv · Oct 13, 2021Biochemistry
L. S. Marmont, G. B. Whitfield, R. Pfoh, R. J. Williams, T. E. Randall, A. Ostaszewski, E. Razvi, R. A. Groves, H. Robinson, M. Nitz, M. R. Parsek, I. A. Lewis, J. C. Whitney, J. J. Harrison, P. L. Howell
The paper identifies PelX as a UDP-GlcNAc C4-epimerase essential for Pel polysaccharide synthesis and biofilm formation in Pseudomonas protegens.
Journal of Biological Chemistry · Aug 1, 2020Peer-reviewedMicrobiology
S. Katharios-Lanwermeyer, G. B. Whitfield, P. L. Howell, G. O'Toole
This study identifies RmcA and MorA as c-di-GMP phosphodiesterases essential for Pseudomonas aeruginosa to maintain mature biofilms under nutrient limitation.
bioRxiv · Jun 26, 2020 · PreprintMicrobiology
M. McCallum, S. Tammam, J. L. Rubinstein, L. L. Burrows, P. L. Howell
The paper determines the structure of PilQ from Pseudomonas aeruginosa and identifies TsaP as the spoke-forming component, revealing its role in surface-sensing signal transduction.
bioRxiv · May 29, 2020Microbiology
G. B. Whitfield, L. S. Marmont, C. Bundalovic-Torma, E. Razvi, E. J. Roach, C. M. Khursigara, J. Parkinson, P. L. Howell
The paper identifies and characterizes a Pel polysaccharide biosynthetic gene cluster in Gram-positive bacteria, showing its role in biofilm formation and regulation by c-di-GMP.
bioRxiv · Sep 18, 2019Microbiology
M. McCallum, S. Benlekbir, S. Nguyen, S. Tammam, J. L. Rubinstein, L. L. Burrows, P. L. Howell
The paper determines four X-ray structures of PilT in different conformations and validates their physiological importance through co-evolution analysis and functional studies.
bioRxiv · Jun 15, 2019Microbiology
R. N. C. Buensuceso, M. Daniel-Ivad, S. L. N. Kilmury, H. Harvey, P. L. Howell, L. L. Burrows
This study shows FimV regulates twitching motility in Pseudomonas aeruginosa independently of cAMP, through polar localization of regulatory proteins and structural components.
bioRxiv · Mar 15, 2017Microbiology
B. D. Snarr, P. Baker, N. C. Bamford, Y. Sato, H. Liu, M. Lehoux, F. N. Gravelat, H. Ostapska, S. R. Baistrocchi, R. P. Cerone, E. E. Filler, M. R. Parsek, S. G. Filler, P. L. Howell, D. C. Sheppard
This study identifies microbial glycoside hydrolases that disrupt biofilms and enhance antifungal efficacy against Aspergillus fumigatus and Pseudomonas aeruginosa.
bioRxiv · Mar 4, 2017Microbiology
T. Carter, R. N. C. Burensuceso, S. Tammam, R. P. Lamers, H. Harvey, P. L. Howell, L. L. Burrows
This study shows that the T4aP machinery is pre-installed at future cell division sites in P. aeruginosa without requiring dedicated peptidoglycan hydrolases.
bioRxiv · Nov 23, 2016Microbiology