R. Lin

Os-circANK negatively regulates resistance to bacterial blight in rice via Osa-miR398b/OsCSD1/OsCSD2 pathways

The paper identifies Os-circANK as a circRNA that suppresses rice resistance to bacterial blight by sponging Osa-miR398b and modulating OsCSD1/OsCSD2 expression.

MARK2 regulates Golgi apparatus reorientation by phosphorylation of CAMSAP2 in directional cell migration

This study identifies MARK2 as a regulator of Golgi reorientation during cell migration by phosphorylating CAMSAP2 at serine 835, affecting its interaction with USO1.

Recognition of RNA secondary structures with a programmable peptide nucleic acid-based platform

This paper introduces daPNAs, a programmable platform combining dbPNAs and asPNAs to target RNA junctions, demonstrating their use in inhibiting Dicer and regulating ribosomal frameshifting.

Ubiquitin-mediated stabilization of SlPsbS regulates low night temperature tolerance in tomatoes

This study identifies a ubiquitin-mediated degradation pathway involving SlCV and SlCSN5A that regulates SlPsbS stability under low night temperatures in tomatoes.

Discovery of Alkenyl Oxindole as a Novel PROTAC Moiety for Targeted Protein Degradation via CRL4DCAF11 Recruitment

The paper develops JQ1-alkenyl oxindole conjugates that degrade BRD4 via the ubiquitin-proteasome system and recruits CRL4DCAF11, identifying HL435 as a potent antitumor lead.

A Vascular Dissection and Rupture Linked Metabolite Acts Via BLT2 Receptor

This study identifies 12-HETE as a key metabolite in thoracic aortic dissection (TAD) that activates BLT2 receptors on macrophages, driving inflammation and VSMC phenotype switching, and shows that targeting this pathway can reduce TAD progression.

Multi-Channel smFRET study reveals a Compact conformation of EF-G on the Ribosome

This study uses multi-channel smFRET to show that EF-G adopts a compact conformation with specific mutations, impacting translocation and Poly(Phe) synthesis.

Pharmacogenomics Guided Spaceflight: the intersection between space-flown drugs and space genes

This paper creates a database of space-flown drugs and identifies spaceflight-related gene targets to advance pharmacogenomics for space missions.

Anthracyclines inhibit SARS-CoV-2 infection

This study identifies anthracyclines as potential SARS-CoV-2 inhibitors through a microbial metabolite screening effort, showing they inhibit viral infection via different mechanisms.

Brain-localized CD4 and CD8 T cells perform correlated random walks and not Levy walks

This study shows brain-localized CD4 and CD8 T cells move via correlated random walks, not Levy walks, challenging previous claims of unique movement strategies in the brain.

Air-Liquid-Interface Reorganizes Membrane Lipid and Enhance Recruitment of Slc26a3 to Lipid-Rich Domains in Human Colon

The paper shows that air-liquid interface culture increases DRA expression and activity in Caco-2/BBe cells and colonoids by enhancing ceramide-rich platform formation and differentiation.

Manipulating Oxalate Decarboxylase Provides the Basis of Antilithic Therapy by Acting on the Gut Microbiota

The paper identifies Zn2+ as a therapeutic agent for calcium oxalate kidney stones by enhancing oxalate-degrading bacteria and their enzymes in the gut microbiota.

The genomes of medicinal skullcaps reveal the polyphyletic origins of clerodane diterpene biosynthesis in the family Lamiaceae.

This study reveals polyphyletic origins of clerodane diterpene biosynthesis in Lamiaceae by analyzing genomes and metabolic pathways of three species.

Analysis of Sexual vs Asexual Reproduction Using Four Measurements

The paper introduces four mathematical measures to compare sexual and asexual reproduction, finding that sexual reproduction leads to greater adaptability and homogeneity.

SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation

This study identifies NSP2-induced repression of Ifnb1 mRNA translation as a mechanism by which SARS-CoV-2 suppresses IFN-β production.

Improved reference genome annotation of Brassica rapa by PacBio RNA sequencing

The paper improves the reference genome annotation of Brassica rapa using PacBio RNA sequencing, identifying novel genes, correcting splicing errors, and characterizing alternative splicing and lncRNAs.

SARS-COV-2 induced Diarrhea is inflammatory, Ca2+ Dependent and involves activation of calcium activated Cl channels

This study investigates the pathophysiology of SARS-CoV-2-induced diarrhea, showing it is inflammatory, calcium-dependent, and involves activation of calcium-activated chloride channels.

EgGLUT1 is crucial for the viability of larvae of Echinococcus granulosus sensus lato by involving its glucose uptake

This study identifies EgGLUT1 as a critical gene for glucose uptake in Echinococcus granulosus s.l. larvae, showing that inhibiting it reduces parasite viability and cyst formation in mice.

TRPM2 promotes pancreatic cancer by PKC/MAPK pathway

This study investigates TRPM2's role in pancreatic cancer, finding it promotes proliferation, migration, and invasion through the PKC/MAPK pathway.

Full three-dimensional imaging deep through multicellular thick samples with subcellular resolution by structured illumination microscopy and adaptive optics

Multiplexed drug testing of tumor slices using a microfluidic platform

This paper develops a microfluidic platform for rapid, multiplexed drug testing of cancer slices to guide personalized therapy.

Saak Transform-Based Machine Learning for Light-Sheet Imaging of Cardiac Trabeculation

This paper develops a Saak transform-based machine learning framework for efficient segmentation and quantification of cardiac trabeculation in light-sheet images after chemotherapy.

Widespread arginine phosphorylation in human cells - a novel protein PTM revealed by mass spectrometry

This study identifies widespread arginine phosphorylation in human cells using a novel phosphoproteomic workflow, revealing 152 high-confidence sites across 118 proteins.

CD155/CD96 promotes immunosuppression in lung adenocarcinoma (LUAD)

This study shows CD155/CD96 promotes immunosuppression in LUAD by inhibiting antitumor immune responses and up-regulating CD96 in CD8 T cells, with potential therapeutic implications.

3D super-resolution microscopy performance and quantitative analysis assessment using DNA-PAINT and DNA origami test samples

Bacteroides fragilis defense against Cronobacter sakazakii -induced pathogenicity by regulating the intestinal epithelial barrier function and attenuating both apoptotic and pyroptotic cell death

This study shows that B. fragilis ZY-312 protects against Cronobacter sakazakii-induced necrotizing enterocolitis by inhibiting invasion, epithelial barrier dysfunction, and dual cell death.

cAMP stimulates SLC26A3 activity in human colon by a CFTR-dependent mechanism that does not require CFTR activity

MiR-126 impairs the intestinal barrier function via inhibiting S1PR2 mediated activation of PI3K/AKT signaling pathway

This study shows miR-126 reduces S1PR2 expression, inhibits PI3K/AKT signaling, and impairs intestinal barrier function in IBD.