S. Gould

Antigen-display exosomes provide adjuvant-free protection against SARS-CoV-2 disease at nanogram levels of spike protein

This study demonstrates that antigen-display exosomes can induce strong neutralizing antibodies and protect against SARS-CoV-2 at nanogram levels of spike protein without adjuvant.

Exomap1 mouse: a transgenic model for in vivo studies of exosome biology

The exomap1 mouse model expresses HsCD81mNG to study exosome biology in vivo, showing cell type-specific exosome contributions and confirming CD81 as an exosome-specific marker.

Syntenin and CD63 Promote Exosome Biogenesis from the Plasma Membrane by Blocking Cargo Endocytosis

This study shows that syntenin and CD63 promote exosome biogenesis by blocking CD63 endocytosis, allowing it to accumulate at the plasma membrane where exosomes originate.

SARS-COV-2 induced Diarrhea is inflammatory, Ca2+ Dependent and involves activation of calcium activated Cl channels

This study investigates the pathophysiology of SARS-CoV-2-induced diarrhea, showing it is inflammatory, calcium-dependent, and involves activation of calcium-activated chloride channels.

Genetic autonomy and low singlet oxygen yield support kleptoplast functionality in photosynthetic sea slugs

The paper investigates how isolated Vaucheria litorea plastids maintain functionality in sea slugs by upregulating key maintenance genes and producing low levels of singlet oxygen.

The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike

This study shows the D614G mutation in SARS-CoV-2 spike enhances lysosomal trafficking and accumulation, contributing to increased infectivity and transmission.

A shared pathway of exosome biogenesis operates at plasma and endosome membranes

This study shows exosomes bud from both plasma and endosome membranes via a shared pathway, explaining their compositional heterogeneity and guiding exosome engineering.