M. Richards

Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions

This study shows that Neuropilin-1 (NRP1) on perivascular cells modulates VEGFA/VEGFR2 signaling in endothelial cells, affecting vascular permeability in a tissue-specific manner.

Trapping studies reveal phenology and reproductive behaviour in two solitary sweat bees (Hymenoptera: Halictidae)

This study uses long-term trapping to examine flight phenology and reproductive behavior in two solitary sweat bees, revealing univoltine and bivoltine life histories and demographic plasticity.

Costs and benefits of maternal nest choice: tradeoffs between brood survival and thermal stress for small carpenter bees

This study examines the tradeoffs of maternal nest site selection in small carpenter bees, finding that sunny nests benefit mothers by reducing nest failure but harm offspring by increasing thermal stress.

Claudin5 protects the peripheral endothelial barrier in an organ and vessel type-specific manner

The paper identifies Claudin5's organ- and vessel-type-specific role in maintaining endothelial barrier integrity through single-cell RNAseq analysis and functional studies in mice.

The novel conserved NAD+ binding micropeptide SGHRT regulates mitochondrial function and metabolism in human cardiomyocytes

Pre-determined macromolecular leakage sites with dynamic properties establish endothelial intra-vessel heterogeneity

The paper identifies pre-determined leakage sites in endothelial cells that show dynamic properties and contribute to intra-vessel heterogeneity, impacting barrier stability and drug delivery.

Phase-separation of EML4-ALK variant 3 is dependent upon an active ALK conformation

This study shows that EML4-ALK V3 forms liquid droplets dependent on ALK's active conformation, and different TKIs affect droplet formation and protein localization differently.

An animal society based on kin competition, not kin cooperation

The paper shows that kin competition drives the evolution of societies based on non-kin cooperation in eastern carpenter bees.

EML4-ALK V3 drives cell migration through NEK9 and NEK7 kinases in non-small-cell lung cancer

The paper shows EML4-ALK V3 promotes cell migration via NEK9 and NEK7 kinases, leading to worse outcomes in lung cancer.

Mitotic phosphorylation by Nek6 and Nek7 reduces microtubule affinity of EML4 to alter spindle dynamics and promote chromosome congression

Increasing phylogenetic stochasticity at high elevations on summits across a remote North American wilderness

The paper analyzes phylogenetic structure in high-alpine plant communities across nine summits, finding stochastic processes dominate but order-specific adaptations also influence community assembly.