Author

N. Steele

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:metabolomics· 2

Frequent Co-Authors

M. Pasca di Magliano· 4 shared C. A. Lyssiotis· 2 shared A. Andren· 1 shared A. Brannon· 1 shared A. Nesvizhskii· 1 shared B. Hu· 1 shared C. J. Halbrook· 1 shared C. L. Pin· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersCancer Biology

M. Pasca di Magliano

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Multi-omic Characterization of Pancreatic Cancer-Associated Macrophage Polarization Reveals Deregulated Metabolic Programs Driven by the GMCSF-PI3K Pathway

S. M. Boyer, H.-J. Lee, N. Steele, L. Zhang, P. Sajjakulnukit, A. Andren, M. H. Ward, V. Basrur, Y. Zhang, A. Nesvizhskii, M. Pasca di Magliano, C. J. Halbrook, C. A. Lyssiotis

This study identifies metabolic markers and pathways in pancreatic tumor-associated macrophages using multi-omic analysis and in vitro models.

bioRxiv · Sep 10, 2021Cancer Biology

Multi-dimensional analyses identify genes of high priority for pancreatic cancer research

Z. C. Nwosu, H. Giza, M. Nassif, V. Charlestin, R. E. Menjivar, D. Kim, S. Kemp, N. Steele, J. Hu, B. Hu, S. Wang, M. Pasca di Magliano, C. A. Lyssiotis

The paper identifies consistently expressed genes in pancreatic ductal adenocarcinoma (PDAC) to prioritize therapeutic targets and biomarkers.

bioRxiv · May 28, 2021 · PreprintCancer Biology

Gastric metabolomics analysis supports H. pyloris catabolism of organic and amino acids in both the corpus and antrum

D. Keilberg, N. Steele, S. Fan, C. Yang, Y. Zavros, K. M. Ottemann

This study compares metabolomics profiles in mouse gastric corpus and antrum organoids and tissue, revealing distinct metabolic differences and H. pylori nutrient utilization patterns.

bioRxiv · Jul 1, 2020 · PreprintMicrobiology

Loss of Activating Transcription Factor 3 prevents KRAS-mediated pancreatic cancer

N. Azizi, J. Toma, M. Martin, M. F. Khalid, N. Steele, J. Shi, M. Pasca Di Magliano, C. L. Pin

This study shows that loss of ATF3 reduces pancreatic cancer progression by limiting acinar-to-ductal metaplasia and enhancing regeneration, but KRASG12D can bypass ATF3's requirement in some contexts.

bioRxiv · Mar 27, 2020Cancer Biology

Beta 1 Integrin Signaling Mediates Pancreatic Ductal Adenocarcinoma Resistance to MEK Inhibition

A. Brannon, D. Drouillard, N. Steele, S. Sutherland, H. Crawford, M. Pasca di Magliano

This study identifies integrin β1 signaling as a mediator of MEK inhibitor resistance in pancreatic cancer organoids, suggesting combination therapy targeting both pathways.

bioRxiv · Jan 6, 2020Cancer Biology