Author

N. Zachos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:cell-cell communication· 2 Assay:proteomics· 2 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

S. Lee· 3 shared J. In· 2 shared J. Yin· 2 shared K. Johnson· 2 shared M. Doucet· 2 shared M. K. Estes· 2 shared O. Kovbasnjuk· 2 shared A. Cox· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersPhysiology

S. Lee

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

SARS-COV-2 induced Diarrhea is inflammatory, Ca2+ Dependent and involves activation of calcium activated Cl channels

M. Donowitz, C.-M. Tse, K. Dokladny, M. Rawat, I. Hurwitz, C. Ye, A. Kell, R. Lin, S. Lee, C. G. Guo, S. J. Tsai, A. Cox, S. Gould, J. In, S. B. Bradfute, , O. Kovbasnjuk

This study investigates the pathophysiology of SARS-CoV-2-induced diarrhea, showing it is inflammatory, calcium-dependent, and involves activation of calcium-activated chloride channels.

bioRxiv · Apr 27, 2021 · PreprintPhysiology

CHRONIC INFLAMMATION IN ULCERATIVE COLITIS CAUSES LONG TERM CHANGES IN GOBLETCELL FUNCTION

V. Singh, K. Johnson, J. Yin, S. Lee, R.-X. Lin, H. Yu, J. In, J. F. Abel, N. Zachos

This study shows that UC colonoids have persistent defects in mucus secretion despite reduced GC numbers, suggesting long-term epithelial dysfunction contributes to UC recurrence.

bioRxiv · Mar 17, 2021Physiology

Coronin-1 is necessary for enteric pathogen-induced transcytosis across human ileal enteroid monolayers expressing M cells

J. F. Staab, M. Doucet, R. Latanich, S. Lee, M. K. Estes, J. B. Kaper, N. Zachos

This study shows that coronin 1a is required for M cell uptake and transcytosis of pathogens in human ileal enteroids, but not commensal bacteria.

bioRxiv · Oct 12, 2020 · PreprintCell Biology

Epithelial and neutrophil interactions and coordinated response to Shigella in a human intestinal enteroid-neutrophil co-culture model

J. M. Lemme-Dumit, M. Doucet, N. Zachos, M. F. Pasetti

This paper develops an ex vivo human intestinal enteroid-PMN co-culture model to study PMN-epithelial interactions and Shigella infection responses, showing PMN phenotypic adaptation and coordinated innate immune responses.

bioRxiv · Sep 3, 2020 · PreprintImmunology

Obesity phenotypes are preserved in intestinal stem cell enteroids from morbidly obese patients

N. Hasan, K. Johnson, J. Yin, N. Baetz, V. Sherman, S. Blutt, M. K. Estes, V. Kumbhari, N. Zachos, O. Kovbasnjuk

The paper identifies obesity-related phenotypes in intestinal stem cell enteroids from morbidly obese patients and shows they retain patient-specific traits post-bariatric surgery.

bioRxiv · May 29, 2020 · PreprintPhysiology