P. Chan

Targeting circadian transcriptional programs in triple negative breast cancer through a cis-regulatory mechanism

This paper identifies a cis-regulatory mechanism in triple-negative breast cancer where targeting circadian transcription factors with small molecules represses a circadian transcriptional program, offering a new therapeutic strategy.

Tumor cell-based liquid biopsy using high-throughput microfluidic enrichment of entire leukapheresis product

This study uses high-throughput microfluidic technology to enrich CTCs from large blood volumes, enabling detailed molecular and morphological analysis of tumor cells in metastatic cancer patients.

Immune Responses in Checkpoint Myocarditis Across Heart, Blood, and Tumor

This study identifies immune cell types and biomarkers in irMyocarditis using single-cell RNA sequencing and TCR analysis across heart, blood, and tumor tissues.

A suite of selective pressures supports the maintenance of alleles of a Drosophila immune peptide

This study investigates the maintenance of diptericin A alleles in Drosophila by analyzing immune responses, sex-specific effects, and microbiome composition across different genotypes.

Discovery of prevalent, clinically actionable tumor neoepitopes via integrated biochemical and cell-based platforms

The paper identifies 84 clinically relevant neoepitope-HLA pairs from 37 shared cancer neoantigens using a combination of biochemical assays and computational methods.