P. Fratzl

Twisted plywood-like tissue formation in vitro. Does curvature do the twist?

This study investigates how surface curvature influences the formation of twisted, multi-layered tissues in vitro using murine pre-osteoblast cells.

3D osteocyte lacunar morphometry of human bone biopsies with high resolution microCT: from monoclonal gammopathy to newly diagnosed multiple myeloma

This study evaluates 3D osteocyte lacunar morphometry in human bone biopsies from monoclonal gammopathy, smoldering multiple myeloma, and newly diagnosed multiple myeloma using high-resolution microCT, finding changes in density, volume, and shape associated with disease progression.

Calcitic prisms of the giant seashell Pinna nobilis form light guide arrays

This study shows that the prismatic layer of Pinna nobilis shells functions as light guides, enhancing optical resolution and contrast for tracking movement.

Induced mineralization in Escherichia coli biofilms: the key role of bacterial alkaline phosphatase

This study shows bacterial alkaline phosphatase (ALP) is essential for mineralization in Escherichia coli biofilms, identified through experiments and imaging techniques.

Submicron-sized in-situ osmotic pressure sensors for in-vitro applications in biology

The paper develops FRET-based liposomal sensors to measure osmotic pressure in cell cultures, demonstrating their effectiveness in pre-osteoblastic systems.

Gradients of orientation, composition and hydration of proteins for efficient light collection by the cornea of the horseshoe crab

The paper demonstrates how structural hierarchy and protein hydration in the cornea of horseshoe crabs enable efficient light collection through graded index optics and total internal reflection.

Collagen Pre-strain Discontinuity at the Cartilage - Bone Interface

The paper identifies a pre-strain gradient in collagen fibrils at the bone-cartilage interface, linking it to biomechanical resilience and osteoarthritis progression.

Three-dimensional interrelationship between osteocyte network and forming mineral during human bone remodeling

The paper uses 3D imaging to study the relationship between osteocyte networks and mineralization in human bone, finding that mineral concentration increases from the LCN and decreases around canaliculi.

Hierarchically-structured metalloprotein composite coatings biofabricated from co-existing condensed liquid phases

The paper investigates the hierarchical structure of mussel byssus cuticle, revealing pre-organized substructures formed through phase separation of protein components in secretory vesicles.

Three-dimensional Structural Interrelations between Cells, Extracellular Matrix and Mineral in Vertebrate Mineralization

This paper uses 3D imaging to study the structural relationships between cells, extracellular matrix, and mineral in avian tendons, revealing a new mechanism for mineralization involving interfibrillar transport of ions and mineral precursors.

Epidermal cell surface structure and chitin-protein co-assembly determine fiber architecture in the Locust cuticle

This study investigates how epidermal cell surface structure and chitin-protein co-assembly influence fiber architecture in locust cuticle, showing both active and passive processes determine the final arrangement.

Surface tension determines tissue shape and growth kinetics

The paper investigates how surface tension influences tissue shape and growth kinetics, showing that even tissues with extracellular matrices can exhibit fluid-like growth behavior.