Author

A. West

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 2 Bioengineering· 1 Biophysics· 1 Physiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Organism:mouse· 7 Research Focus:drug response / drug discovery· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:benchmarking· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

S. R. Leist· 6 shared K. H. Dinnon· 4 shared K. L. Gully· 4 shared D. R. Martinez· 3 shared R. S. Baric· 3 shared S. A. Montgomery· 3 shared A. J. Brown· 2 shared A. Schaefer· 2 shared

Activity by Year

2018-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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6 shared papersMicrobiology

S. R. Leist

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Author profile →

11 papers

Recent·Most cited

Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice

A. J. Brown, J. Won, R. Wolfisberg, U. Fanhoe, N. Catanzaro, A. West, F. Moreira, M. Nogeuira Batista, M. T. Ferris, C. Linnertz, S. R. Leist, C. Nguyen, G. De la Cruz, B. Midkiff, Y. Xia, , T. P. Sheahan

The paper infects diverse mouse strains with a hepacivirus and shows host genetic variation influences viral clearance, chronicity, and liver fibrosis outcomes.

bioRxiv · Mar 18, 2023Microbiology

Fc mediated pan-sarbecovirus protection after alphavirus vector vaccination

L. E. Adams, S. R. Leist, K. H. Dinnon, A. West, K. L. Gully, E. Anderson, J. F. Loome, E. Madden, J. Powers, A. Schaefer, S. Sarkar, I. Castillo, J. Maron, R. P. McNamara, H. L. Bertera, , R. S. Baric

This study shows that non-neutralizing antibodies targeting FcR4 and spike S2 provide cross-protection against sarbecoviruses after alphavirus vector vaccination.

bioRxiv · Nov 28, 2022Microbiology

A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategies

K. H. Dinnon, S. R. Leist, K. Okuda, H. Dang, E. J. Fritch, K. L. Gully, G. Cruz, M. D. Evangelista, T. Asakura, R. C. Gilmore, P. Hawkins, S. Nakano, A. West, A. Schäfer, L. E. Gralinski, , Montg

This paper develops a murine model of persistent post-SARS-CoV-2 lung disease to identify therapeutic targets and test interventions for PASC.

bioRxiv · Feb 15, 2022 · PreprintMicrobiology

Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice

D. R. Martinez, A. Schaefer, S. R. Leist, G. De la Cruz, A. West, E. N. Atochina-Vasserman, L. C. Lindesmith, N. Pardi, R. Parks, M. Barr, D. Li, B. Yount, K. O. Saunders, D. Weissman, B. Haynes, , R. S. Baric

This study shows chimeric spike mRNA vaccines protect mice against multiple Sarbecovirus strains, including variants and zoonotic viruses, better than standard SARS-CoV-2 vaccines.

bioRxiv · Mar 11, 2021Microbiology

SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

K. S. Corbett, D. Edwards, S. R. Leist, O. M. Abiona, S. Boyoglu-Barnum, R. A. Gillespie, S. Himansu, A. Schafer, C. T. Ziwawo, A. T. DiPiazza, K. H. Dinnon, S. M. Elbashir, C. A. Shaw, A. Woods, E. J. Fritch, , Wang

This paper describes the development of an mRNA vaccine (mRNA-1273) against SARS-CoV-2, showing it induces neutralizing antibodies and CD8 T cell responses and protects mice from infection.

bioRxiv · Jun 11, 2020Immunology

Convergent Antibody Responses to SARS-CoV-2 Infection in Convalescent Individuals

D. F. Robbiani, C. Gaebler, F. Muecksch, J. Cetrulo Lorenzi, Z. Wang, A. Cho, M. Agudelo, C. Barnes, S. Finkin, T. Hagglof, T. Oliveira, C. Viant, A. Hurley, K. Millard, R. Kost, , Nuss

The paper analyzes antibody responses in convalescent individuals, finding low neutralizing titers but rare potent RBD-specific antibodies with broad antiviral potential.

bioRxiv · May 13, 2020Immunology

A mouse-adapted SARS-CoV-2 model for the evaluation of COVID-19 medical countermeasures

K. H. Dinnon, S. R. Leist, A. Schafer, C. E. Edwards, D. R. Martinez, S. A. Montgomery, A. West, B. L. Yount, Y. J. Hou, L. E. Adams, K. L. Gully, A. J. Brown, E. Huang, M. D. Bryant, I. C. Choong, , R. S. Baric

This paper develops a mouse-adapted SARS-CoV-2 model to evaluate medical countermeasures, showing age-related disease severity and the efficacy of IFN lambda-1a.

bioRxiv · May 6, 2020Microbiology

Photoperiod-dependent developmental reprogramming of the transcriptional response to seawater entry in Atlantic salmon (Salmo salar)

D. G. Hazlerigg, S. R. Sandve, S. Martin, M. Iversen, A. West, E. Jorgensen, T. mulugeta

The paper examines how photoperiod affects the transcriptional response to seawater entry in Atlantic salmon, finding that short photoperiod impairs hypo-osmoregulation and alters gill gene expression.

bioRxiv · Mar 24, 2020Physiology

Insecticide-free trapping bed-net can mitigate insecticide resistance threat in malaria vector control strategies

C. Mouhamadou, K. Luan, B. K. Fodjo, A. West, M. McCord, C. Apperson, M. Roe

This study designs and tests an insecticide-free bed-net that uses an attract-trap-kill mechanism to combat pyrethroid-resistant malaria mosquitoes, showing significantly greater efficacy than traditional insecticide-treated nets.

bioRxiv · Feb 6, 2020 · PreprintBioengineering

Comparison of efficiency and specificity of CRISPR-associated (Cas) nucleases in plants: An expanded toolkit for precision genome engineering

O. Raitskin, C. Schudoma, A. West, N. J. Patron

This study compares the efficiency and specificity of CRISPR-associated nucleases in plants, finding that Staphylococcus aureus Cas9 is most efficient and high-fidelity variants reduce off-target mutations.

bioRxiv · Nov 7, 2018Plant Biology

Surface tension determines tissue shape and growth kinetics

S. Ehrig, C. M. Bidan, A. West, C. Jacobi, K. Lam, P. Kollmannsberger, A. Petersen, P. Tomancak, K. Kommareddy, F. D. Fischer, P. Fratzl, J. W. C. Dunlop

The paper investigates how surface tension influences tissue shape and growth kinetics, showing that even tissues with extracellular matrices can exhibit fluid-like growth behavior.

bioRxiv · Oct 29, 2018Biophysics