Author

P. Goulder

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 3

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:statistical model· 5 Research Focus:differential expression· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Assay:flow cytometry· 2

Frequent Co-Authors

P. Klenerman· 4 shared E. Adland· 3 shared A. Csala· 2 shared E. Barnes· 2 shared J. Frater· 2 shared N. Grayson· 2 shared T. Ndung'u· 2 shared A. Amini· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersMicrobiology

P. Klenerman

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Author profile →

7 papers

Recent·Most cited

Gonadal androgens are associated with decreased type I interferon production by pDCs and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents

O. L. Sampson, C. Jay, E. Adland, A. Csala, N. Lim, S. M. Ebbrecht, L. C. Gilligan, A. E. Taylor, S. S. George, S. Longet, L. C. Jones, E. Barnes, J. Frater, P. Klenerman, S. Dunachie, , P. Goulder

The paper investigates how gonadal androgens affect type I interferon production by pDCs and IgG titres to BNT162b2 in adolescents co-vaccinated with LAIV.

bioRxiv · Aug 1, 2023 · PreprintImmunology

Further antibody escape by Omicron BA.4 and BA.5 from vaccine and BA.1 serum

A. Tuekprakhon, J. Huo, R. Nutalai, A. Dijokaite-Guraliuc, D. Zhou, H. M. Ginn, M. Sekvaraj, C. Liu, A. J. Mentzer, P. Supasa, H. M. E. Duyvesteyn, R. Das, D. Skelly, T. G. Ritter, A. Amini, , G. R. Screaton

This study shows that BA.4 and BA.5 variants are more resistant to neutralization by vaccine and BA.1 immune sera compared to BA.1 and BA.2.

bioRxiv · May 21, 2022 · PreprintMicrobiology

Determinants of precocious B-cell aging in European adolescences living with perinatally acquired HIV-1 after over 10 years of suppressive therapy

A. Ruggiero, G. R. Pascucci, N. Cotugno, S. Dominguez-Rodriguez, R. Stefano, A. Tagarro Garcia, P. Rojo, C. Foster, A. Bamford, A. De Rossi, E. Nastouli, K. Nigel, M. Elena, B. Fatou, K. K. Smolen, , included in the manuscript

This study identifies factors associated with precocious B-cell aging in adolescents with perinatally acquired HIV on long-term suppressive therapy, linking them to immune dysfunction and reduced vaccine response.

bioRxiv · Nov 11, 2021 · PreprintImmunology

HIV-specific CD8+ T-cells in tonsils express exhaustive TRM-like signatures

R. Fardoos, S. K. Nyquist, O. E. Asowata, S. W. Kazer, A. Singh, A. N. Ngoepe, J. G. Giandhari, N. M. Mthabela, D. Ramjit, S. Singh, F. Karim, S. Buus, F. Anderson, J. Z. Porterfield, A. L. Sibiya, , H. N. Kloverpris

The paper examines HIV-specific CD8+ T-cells in tonsils, finding they exhibit TRM-like exhaustion signatures compared to blood, with differences in natural HIV controllers.

bioRxiv · Nov 4, 2021 · PreprintImmunology

Expression of type I interferon-associated genes at antiretroviral therapy interruption predicts HIV virological rebound

P. Zacharopoulou, E. Marchi, A. Ogbe, N. Robinson, H. Brown, M. Jones, L. Parolini, M. Pace, N. Grayson, P. Kaleebu, H. Rees, S. Fidler, P. Goulder, P. Klenerman, J. Frater

The paper identifies type I interferon-associated gene expression in CD4 T cells as a predictor of delayed HIV viral rebound after antiretroviral therapy interruption.

bioRxiv · Nov 24, 2020 · PreprintMicrobiology

Low Replication Capacity Virus Is Preferentially Transmitted In Mother-To-Child-Transmission But Not In Adult-To-Adult-Transmission Of HIV-1

E. Adland, L. Iselin, F. Roxburgh, J. Millar, A. Csala, V. Naidoo, C. Noble, J. Thomas, A. De'Felice, A. Szabo, N. Grayson, A. Moodley, K. Dong, B. Walker, T. Ndung'u, , P. Goulder

The paper compares viral replicative capacity in mother-to-child and adult-to-adult HIV-1 transmission, finding lower replicative capacity in MTCT viruses.

bioRxiv · Jan 3, 2019 · PreprintImmunology

HBV vaccination and PMTCT as elimination tools in the presence of HIV: insights from a clinical cohort and dynamic model

A. McNaughton, J. Lourenco, L. Hattingh, E. Adland, S. Daniels, A. van Zyl, C. S. Akiror, S. Wareing, K. Jeffery, A. Ansari, P. Klenerman, P. Goulder, S. Gupta, P. Jooste, P. C. Matthews

This study evaluates HBV vaccination and PMTCT as tools for elimination in HIV-coinfected populations using a clinical cohort and dynamic model, showing potential for significant public health impact by 2030.

bioRxiv · Sep 24, 2018Microbiology