Author

E. Barnes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Evolutionary Biology· 2 Immunology· 2 Ecology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 9 Approach:experimental assay· 6 Approach:statistical model· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:metagenomics· 2 Research Focus:phylogenetics / evolution· 2

Frequent Co-Authors

P. Klenerman· 4 shared M. A. Ansari· 3 shared A. Amini· 2 shared A. Ansari· 2 shared A. J. Pollard· 2 shared J. Mokaya· 2 shared P. C. Matthews· 2 shared P. Goulder· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersImmunology

P. Klenerman

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Gonadal androgens are associated with decreased type I interferon production by pDCs and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents

O. L. Sampson, C. Jay, E. Adland, A. Csala, N. Lim, S. M. Ebbrecht, L. C. Gilligan, A. E. Taylor, S. S. George, S. Longet, L. C. Jones, E. Barnes, J. Frater, P. Klenerman, S. Dunachie, , P. Goulder

The paper investigates how gonadal androgens affect type I interferon production by pDCs and IgG titres to BNT162b2 in adolescents co-vaccinated with LAIV.

bioRxiv · Aug 1, 2023 · PreprintImmunology

Further antibody escape by Omicron BA.4 and BA.5 from vaccine and BA.1 serum

A. Tuekprakhon, J. Huo, R. Nutalai, A. Dijokaite-Guraliuc, D. Zhou, H. M. Ginn, M. Sekvaraj, C. Liu, A. J. Mentzer, P. Supasa, H. M. E. Duyvesteyn, R. Das, D. Skelly, T. G. Ritter, A. Amini, , G. R. Screaton

This study shows that BA.4 and BA.5 variants are more resistant to neutralization by vaccine and BA.1 immune sera compared to BA.1 and BA.2.

bioRxiv · May 21, 2022 · PreprintMicrobiology

Soil fungal communities vary more with soil characteristics than tree diversity at a local scale

S. Kutos, E. Barnes, J. Lewis

The paper examines how soil fungal communities and enzymatic activity are influenced by soil characteristics and plant identity in a mixed-hardwood woodland.

bioRxiv · Jan 26, 2022Ecology

FXR inhibition reduces ACE2 expression, SARS-CoV-2 infection and may improve COVID-19 outcome

T. Brevini, M. Maes, G. J. Webb, W. T. H. Gelson, S. Forrest, P. Mlcochova, S. Dillon, S. Varankar, M. Darvish-Damavandi, V. L. Mulcahy, R. E. Kuc, T. L. Williams, V. Galanakis, M. Vila-Gonzalez, O. C. Tysoe, , F. Sampaziotis

This study shows FXR inhibition lowers ACE2 expression, reduces SARS-CoV-2 infection, and correlates with better clinical outcomes in COVID-19.

bioRxiv · Jun 6, 2021 · PreprintMicrobiology

Global spread and evolutionary history of HCV subtype 3a

S.-K. Lin, N. De Maio, V. Pedergnana, C.-H. Wu, J. Theze, E. Barnes, A. Ansari

The paper uses host and virus genomic data to trace the global spread and evolutionary history of HCV subtype 3a, finding it originated in South Asia and spread through three independent events post-World War II.

bioRxiv · Feb 3, 2021 · PreprintEvolutionary Biology

Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations

J. Mokaya, T. I. Vasylyeva, E. Barnes, M. A. Ansari, O. G. Pybus, P. C. Matthews

This study analyzes the global prevalence and phylogeny of HBV drug and vaccine resistance mutations, finding high prevalence in genotype C and evidence of independent emergence of resistance mutations.

bioRxiv · Oct 7, 2020Evolutionary Biology

Autophagy in T cells from aged donors is maintained by spermidine, and correlates with function and vaccine responses

G. Alsaleh, I. Panse, L. Swadling, H. Zhang, A. Meyer, J. Lord, E. Barnes, P. Klenerman, C. Green, K. Simon

This study shows that spermidine maintains autophagy in aged human T cells, improving vaccine responses by enhancing IFN-gamma secretion and T cell function.

bioRxiv · Jun 1, 2020Physiology

Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure

D. A. Smith, A. Magri, R. Bowden, N. Chaturvedi, J. Fellay, J. McLauchlan, G. R. Foster, W. L. Irving, STOP-HCV Consortium, P. Simmonds, V. Pedergnana, E. Barnes, M. A. Ansari

This study identifies three HCV polymorphisms in NS2 and NS3 proteins associated with sofosbuvir treatment failure using whole genome sequencing of 507 patients.

bioRxiv · May 5, 2020Microbiology

Targeted metagenomic sequencing enhances the identification of pathogens associated with acute infection.

C. Goh, T. Golubchik, M. A. Ansari, M. de Cesare, A. Trebes, I. Elliott, D. Bonsall, P. Piazza, A. Brown, H. Slawinski, N. Martin, S. Defres, M. J. Griffiths, J. E. Bray, M. C. Maiden, , R. Bowden

Castanet, a targeted metagenomic sequencing method, improves pathogen detection in clinical samples by combining sensitivity with cost-effectiveness and broad organism coverage.

bioRxiv · Jul 28, 2019 · PreprintMicrobiology

Activation of MAIT cells plays a critical role in viral vector vaccine immunogenicity

N. Provine, A. Amini, L. Garner, C. Dold, C. Hutchings, M. FitzPatrick, L. Silva Reyes, S. Chinnakannan, B. Oguti, M. Raymond, S. Capone, A. Folgori, C. Rollier, E. Barnes, A. Pollard, P. Klenerman

This study shows that MAIT cell activation is essential for the immunogenicity of adenovirus vector vaccines, as it drives HCV-specific CD8 T cell responses.

bioRxiv · Jun 13, 2019 · PreprintImmunology

Data from an electronic health informatics pipeline to describe clearance dynamics of Hepatitis B surface antigen (HBsAg) and e-Antigen (HBeAg) in chronic HBV infection

L. O. Downs, D. Smith, S. F. Lumley, M. Patel, A. L. McNaughton, J. Mokaya, A. Ansari, H. Salih, K. A. Varnai, O. Freeman, S. Cripps, J. Phillips, J. Collier, K. Woods, K. Channon, , P. C. Matthews

The paper describes an electronic health informatics pipeline that collects longitudinal clinical data on HBsAg and HBeAg clearance in chronic HBV infection, revealing demographic and treatment-related factors associated with clearance.

bioRxiv · Mar 26, 2019Microbiology