Author

P. Kuzmic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

B. Liu· 1 shared B. Zhou· 1 shared C. Long· 1 shared C. Niu· 1 shared C. Yang· 1 shared H. Jiang· 1 shared H. Li· 1 shared H. Xu· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

B. Liu

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4 papers

Recent·Most cited

Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor

X. Chen, X. Huang, Q. Ma, P. Kuzmic, B. Zhou, J. Xu, B. Liu, H. Jiang, W. Zhang, C. Yang, S. Wu, J. Huang, H. Li, C. Long, X. Zhao, , N. Zhong

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

bioRxiv · Mar 9, 2023Biochemistry

A two-point IC50 method for evaluating the biochemical potency of irreversible enzyme inhibitors

P. Kuzmic

The paper introduces a two-point IC50 method to distinguish the potency of irreversible enzyme inhibitors by estimating binding affinity and chemical reactivity from two IC50 values.

bioRxiv · Jun 25, 2020 · PreprintBiochemistry

A steady-state algebraic model for the time course of covalent enzyme inhibition

P. Kuzmic

The paper presents a steady-state algebraic model for irreversible enzyme inhibition, showing that the conventional kobs method fails to distinguish between two-step and one-step inhibition mechanisms when inactivation is fast.

bioRxiv · Jun 10, 2020 · PreprintBiochemistry

Deciding between one-step and two-step irreversible inhibition mechanisms on the basis of "kobs" data: A statistical approach

P. Kuzmic

The paper presents a statistical method to distinguish between one-step and two-step irreversible inhibition mechanisms using kobs data, revealing errors in previously published results for ibrutinib and acalabrutinib.

bioRxiv · Jun 8, 2020 · PreprintBiochemistry