Author

N. Zhong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biochemistry· 1 Bioengineering· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Research Focus:drug response / drug discovery· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. Liu· 4 shared T. zhang· 4 shared J. Hu· 3 shared B. Liu· 2 shared B. Zhou· 2 shared C. Fang· 2 shared H. M. A. Hameed· 2 shared H. Zhang· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersBiochemistry

J. Liu

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Establishment of an Inhalation Administration Noninvasive Murine Model for Rapidly Testing Drug Activity against Mycobacterium tuberculosis

X. Tian, Y. Gao, W. Ma, J. Zhang, Y. Ju, J. Ding, S. Zeng, A. Hameed, N. Zhong, G. M. Cook, J. Hu, T. zhang

This paper develops a non-invasive murine inhalation model using autoluminescent M. tuberculosis to rapidly assess drug efficacy against tuberculosis.

bioRxiv · Feb 27, 2024 · PreprintMicrobiology

Mutations in ClpC1 or ClpX subunit of the caseinolytic protease confer resistance to natural product ilamycins in mycobacteria

Y. Gao, C. Fang, B. Zhou, H. M. A. Hameed, C. Sun, X. Tian, J. He, X. Han, H. Zhang, J. Li, J. Ju, X. Chen, N. Zhong, J. Ma, X. Xiong, T. Zhang

This study identifies two ilamycin analogs targeting mycobacterial Clp protease components and discovers mutations conferring resistance to these compounds.

bioRxiv · Feb 24, 2024 · PreprintMicrobiology

Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor

X. Chen, X. Huang, Q. Ma, P. Kuzmic, B. Zhou, J. Xu, B. Liu, H. Jiang, W. Zhang, C. Yang, S. Wu, J. Huang, H. Li, C. Long, X. Zhao, , N. Zhong

This study identifies RAY1216, a slow-tight SARS-CoV-2 Mpro inhibitor with improved pharmacokinetics and antiviral activity compared to PF-07321332, currently in phase III clinical trials.

bioRxiv · Mar 9, 2023Biochemistry

An engineered xCas12i with high activity, high specificity and broad PAM range

H. Zhang, X. Kong, M. Xue, Z. Wang, Y. Wei, H. Wang, J. Zhou, W. Zhang, M. Xu, X. Shen, J. Li, J. Hu, N. Zhong, Y. Zhou, H. Yang

This paper identifies and engineers a high-fidelity Cas12i variant with broad PAM recognition and minimal off-target activity for improved genome editing.

bioRxiv · Jun 15, 2022Bioengineering

Spatiotemporal landscape of SARS-CoV-2 pulmonary infection reveals Slamf9+Spp1+ macrophages promoting viral clearance and inflammation resolution

B. Cong, X. Dong, Z. Yang, P. Yu, Y. Chai, J. Liu, M. Zhang, Y. Zang, J. Kang, Y. Feng, Y. Liu, W. Feng, W. Deng, F. Li, Q. Yu, , X. Cao

This study identifies Slamf9+Spp1+ macrophages in hamsters that promote SARS-CoV-2 clearance and inflammation resolution through spatial transcriptomics and scRNA-seq.

bioRxiv · May 3, 2022 · PreprintImmunology

Aucubin promoted neuron functional recovery by suppressing inflammation and neuronal apoptosis in a spinal cord injury model

S. Xiao, N. Zhong, Q. Yang, A. Li, W. Tong, Y. Zhang, G. Yao, S. Wang, J. Liu, Z. Liu

This study shows that aucubin promotes functional recovery after spinal cord injury by reducing inflammation and neuronal apoptosis through the TLR4/NF-κB pathway and mitochondrial protection.

bioRxiv · Feb 1, 2022Cell Biology

A recombinant selective drug-resistant M. bovis BCG enhances the bactericidal activity of a second-line tuberculosis regimen

G. Chiwala, Z. Liu, J. N. Mugweru, B. Wang, S. A. Khan, P. N. N. Bate, B. Yusuf, H. M. A. Hameed, C. Fang, Y. Tan, P. Guan, J. Hu, S.-Y. Tan, J. Liu, N. Zhong, T. Zhang

This study develops a drug-resistant recombinant BCG vaccine that enhances second-line TB treatment efficacy in a murine model of drug-resistant tuberculosis.

bioRxiv · Mar 4, 2021Microbiology

Incidence and Characteristics of Co-infection and Secondary Infection in Patients with COVID-19

Y. Guo, J. Qu, L. Cheng, X. Li, N. Liu, T. Li, Y. Jiang, Q. Wan, C. Zhuo, S. Xiao, B. Liu, Y. Chen, l. Fu, Z. Chen, M. Ma, , N. Zhong

This study examines co-infection and secondary infection rates in COVID-19 patients, finding low rates of Streptococcus pneumoniae co-infections and common secondary pathogens like S. maltophilia.

bioRxiv · Jan 6, 2021 · PreprintMicrobiology

In vitro activities of the tetrazole SHR8008 compared to itraconazole and fluconazole against Candida and Cryptococcus species

L. Wang, M. Zhang, J. Guo, W. Guo, N. Zhong, H. Shen, W. Wu

This study compares the in vitro antifungal activity of SHR8008, a novel tetrazole, to itraconazole and fluconazole against Candida and Cryptococcus species, finding SHR8008 to be significantly more potent.

bioRxiv · Jan 15, 2020Microbiology