Author

P. MacDonald

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:differential expression· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

A. Spigelman· 2 shared A. Bautista· 1 shared A. Benrick· 1 shared A. J. Waardenberg· 1 shared A. Kim· 1 shared B. B. Lowell· 1 shared B. Rollo· 1 shared C. Miranda· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

A. Spigelman

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Acid sensing ion channel 1a is a key mediator of cardiac ischemia-reperfusion injury

M. Redd, S. Scheuer, N. Saez, H. Chiu, L. Gao, M. Hicks, J. Villanueva, G. Cuellar-Partida, J. Peart, L. See Hoe, X. Chen, Y. Sun, J. Suen, R. Hatch, B. Rollo, , N. Palpant

This study shows ASIC1a contributes to cardiac ischemia-reperfusion injury and that inhibiting it protects heart function, with genetic variants linked to myocardial infarction.

bioRxiv · Nov 17, 2020Physiology

Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes

A. Kim, J. G. Knudsen, J. C. Madara, A. Benrick, T. Hill, L. Abdul Kadir, J. A. Kellard, L. Mellander, C. Miranda, H. Lin, T. James, K. Suba, A. Spigelman, Y. Wu, P. MacDonald, , L. Briant

This study identifies arginine-vasopressin as a systemic regulator of glucagon secretion, showing its role in counter-regulatory responses to hypoglycemia and its impairment in type 1 diabetes.

bioRxiv · Jan 30, 2020Cell Biology

Aging of human endocrine pancreatic cell types is heterogeneous and sex-specific

R. Arrojo e Drigo, G. Erikson, S. Tyagi, J. Capitanio, J. Lyon, A. Spigelman, A. Bautista, J. E. Manning Fox, M. Shokhirev, P. MacDonald, M. Hetzer

This study analyzes age-related changes in human endocrine pancreatic cell types, finding sex-specific and cell-type-specific effects of aging on beta cell function and transcriptional profiles.

bioRxiv · Aug 8, 2019 · PreprintPhysiology

PDGFR alpha signaling in cardiac fibroblasts modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repair

N. S. Asli, M. Xaymardan, R. Patrick, N. Farbehi, J. Cornwell, E. Forte, A. J. Waardenberg, V. Janbandhu, S. Kesteven, V. Chandrakanthan, H. Malinowska, H. Reinhard, P. Schofield, D. Christ, I. Ahmed, , R. P. Harvey

This study investigates how PDGFR alpha signaling in cardiac fibroblasts affects quiescence, metabolism, and self-renewal, leading to improved heart repair after myocardial infarction.

bioRxiv · Jun 13, 2019 · PreprintCell Biology