P. W. Noble

This study creates a single-cell transcriptional atlas of human lungs across ages, revealing age-related dysregulation in AT2 cells and their niche, including increased senescence and inflammation.

This study shows a lupus anti-DNA autoantibody activates cGAS and improves survival in glioblastoma models by enhancing CD8+ T cell infiltration.

This study identifies metabolic defects in alveolar progenitor cells during aging and lung injury that impair their renewal capacity.

This study identifies fibroblast subpopulations in mouse and human lungs using scRNA-seq, revealing conserved transcriptomic signatures and their roles in fibrosis.

This study shows that senescence of alveolar type 2 stem cells drives pulmonary fibrosis and that targeting p53 or Tgfβ can block fibrogenesis.