Author

R. C. Fields

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

L. Ding· 3 shared A. Alarcon de la Lastra· 2 shared B. L. Knolhoff· 2 shared C. Zuo· 2 shared D. G. DeNardo· 2 shared J. M. Baer· 2 shared A. James· 1 shared C. Cunningham· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

L. Ding

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Pancreas resident macrophage-induced fibrosis has divergent roles in pancreas inflammatory injury and PDAC

J. M. Baer, C. Zuo, L.-I. Kang, A. Alarcon de la Lastra, N. C. Borcherding, B. L. Knolhoff, S. J. Bogner, Y. Zhu, M. A. Lewis, N. Zhang, K.-w. Kim, R. C. Fields, J. C. Mills, L. Ding, G. J. Randolph, D. G. DeNardo

This study shows that pancreas resident macrophages (TRMs) have distinct roles in pancreatitis and pancreatic cancer, promoting fibrosis in inflammation but driving cancer progression.

bioRxiv · Feb 9, 2022 · PreprintImmunology

Macrophage proliferation machinery leads to PDAC progression, but susceptibility to innate immunotherapy.

D. G. DeNardo, C. Zuo, J. M. Baer, B. L. Knolhoff, J. I. Belle, X. Liu, G. D. Hogg, C. Fu, N. L. Kingston, M. A. Brenden, A. Alarcon De La Lastra, P. B. Dodhiawala, C. Zhou, A. James, L. Ding, , J. D. Weber

This study shows that TAM proliferation in PDAC is driven by CSF1 from fibroblasts, leading to immunosuppression and tumor progression, but also increasing sensitivity to CD40 agonist therapy.

bioRxiv · Nov 8, 2021 · PreprintCancer Biology

Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression

Y. Bi, V. S. Shirure, R. Liu, C. Cunningham, L. Ding, M. Meacham, P. Goedegebuure, S. C. George, R. C. Fields

This study uses a tumor-on-a-chip platform to show that M1 macrophages inhibit tumor growth and angiogenesis, while M2 macrophages promote tumor migration and angiogenesis through distinct molecular mechanisms.

bioRxiv · May 27, 2020Cancer Biology