R. Hansen

Rampant transcription replication conflict creates therapeutic vulnerability in extrachromosomal DNA containing cancers

This paper identifies transcription-replication conflict as a vulnerability in ecDNA-containing cancers and demonstrates that CHK1 inhibition selectively kills these tumors.

An array of Zymoseptoria tritici effectors suppress plant immune responses

The paper identifies Zymoseptoria tritici effectors that suppress plant immune responses by screening libraries and analyzing structural predictions.

Transatlantic spread of highly pathogenic avian influenza H5N1 by wild birds from Europe to North America in 2021

The paper reports the detection of H5N1 HPAI viruses in Canada linked to European strains, suggesting transatlantic spread by wild birds and raising concerns for further spread in the Americas.

Systemic infection with highly pathogenic H5N8 of avian origin produces encephalitis and mortality in wild mammals at a UK rehabilitation centre

The paper reports that systemic infection with H5N8 avian influenza virus caused encephalitis and mortality in wild mammals at a UK wildlife rehabilitation centre.

A dispensable paralog of succinate dehydrogenase subunit C mediates standing resistance towards a subclass of SDHI fungicides in Zymoseptoria tritici

This study identifies a paralog of the SDH C subunit in Zymoseptoria tritici that mediates resistance to a subclass of SDHI fungicides and shows its impact on resistance phenotypes through polymorphisms and promoter transposon insertions.

Propionic acid promotes the virulent phenotype of Crohns disease-associated adherent-invasive Escherichia coli

This study shows that propionic acid exposure increases virulence in adherent-invasive Escherichia coli, leading to higher persistence in mice and altered gene expression.