S. Hester

Lysosomal signaling pathways influence heart rhythm, and regulate atrial function

This study investigates the role of lysosomal Ca2+ signaling in heart rhythm and atrial function, finding that NAADP pathway inhibition affects SAN pacemaker activity and cAMP production in atrial myocytes.

Activation of IP3R in atrial cardiomyocytes leads to generation of cytosolic cAMP

This study shows that IP3R activation in atrial myocytes increases cAMP, which can be inhibited by IP3R blockers, but ventricular myocytes show cAMP increases independent of IP3R.

Extracellular vesicles from patients with coronary artery disease (CAD) demonstrate enhanced pro-coagulatory activity.

This study finds that extracellular vesicles from CAD patients show increased pro-coagulatory activity despite similar numbers to controls, suggesting a role in CAD pathogenesis.

Loss of FAM111B protease mutated in hereditary fibrosing poikiloderma syndrome negatively regulates telomere length

This study identifies FAM111B as a regulator of telomere length through interactions with the nuclear pore complex, independent of telomerase, and links its dysfunction to genomic instability in HFP patients.

MR1 dependent MAIT cell activation is regulated by autophagy associated proteins

The paper identifies SQSTM1/p62 as an MR1 interacting protein and shows its role in regulating MAIT cell activation through autophagy pathways.

Synthetic antigen presenting cells reveal the diversity and functional specialisation of extracellular vesicles composing the fourth signal of T cell immunological synapses.

This study uses synthetic antigen-presenting cells to analyze the composition and functional specialization of extracellular vesicles released during T cell immunological synapses.

KAT2-mediated acetylation switches the mode of PALB2 chromatin association to safeguard genome integrity

This study shows that KAT2A/B acetylates PALB2 to regulate its chromatin association, enhancing DNA repair and genome stability.