Author

S. O'Toole

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Research Focus:benchmarking· 2 Research Focus:clustering· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

K. Harvey· 5 shared A. Swarbrick· 4 shared C.-L. Chan· 4 shared E. Lim· 4 shared A. S. Cazet· 3 shared D. L. Roden· 3 shared G. Al-Eryani· 3 shared J. Powell· 3 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCancer Biology

K. Harvey

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6 papers

Recent·Most cited

Macropinocytosis mediates resistance to loss of glutamine transport in triple-negative breast cancer

K. Wahi, N. Freidman, Q. Wang, M. Devadason, L.-E. Quek, A. Pang, L. Lloyd, M. Larance, F. Zanini, K. Harvey, S. O'Toole, Y. F. Guan, J. Holst

The paper shows that TNBC cells compensate for loss of ASCT2 glutamine uptake by increasing macropinocytosis, suggesting resistance to targeting glutamine transport alone.

bioRxiv · Feb 21, 2024Cancer Biology

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

V. M. Saini, E. Oner, M. Ward, S. Hurley, B. D. Henderson, F. Lewis, S. P. Finn, J. O'Leary, S. O'Toole, L. O'Driscoll, K. Gately

This study compares five CTC isolation technologies in lung cancer, finding CellMag and Parsortix PR1 have the highest recovery rates.

bioRxiv · Feb 5, 2024Cancer Biology

An experimental comparison of the Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research

T. Wang, K. Harvey, J. Reeves, D. L. Roden, N. Bartonicek, J. Yang, G. Al-Eryani, D. Kaczorowski, C.-L. Chan, J. Powell, S. O'Toole, E. Lim, A. Swarbrick

This study compares Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research, finding differences in sensitivity, specificity, and application suitability.

bioRxiv · Apr 6, 2023 · PreprintCancer Biology

Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer

S. Z. Wu, D. L. Roden, C. Wang, H. Holliday, K. Harvey, A. S. Cazet, K. J. Murphy, B. Pereira, G. Al-Eryani, N. Bartonicek, R. Hou, J. R. Torpy, S. Junankar, C.-L. Chan, E. Lam, , A. Swarbrick

This study identifies diverse stromal subsets in TNBC using single-cell RNA-seq and links them to immune evasion mechanisms and therapeutic targets.

bioRxiv · Jun 4, 2020Cancer Biology

Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis

S. Z. Wu, D. L. Roden, G. Al-Eryani, N. Bartonicek, K. Harvey, A. S. Cazet, C.-L. Chan, S. Junankar, M. N. Hui, E. Millar, J. Beretov, L. Horvath, A. M. Joshua, P. Stricker, J. S. Wilmott, , A. Swarbrick

This study shows that cryopreservation of human cancers preserves tumour heterogeneity for single-cell multi-omics analysis, with comparable results to fresh tissue.

bioRxiv · Jun 4, 2020Cancer Biology

Targeting stromal remodeling and cancer stem cell plasticity to overcome chemoresistance in triple negative breast cancer

A. S. Cazet, M. N. Hui, B. L. Elsworth, S. Z. Wu, D. Roden, C.-L. Chan, J. N. Skhinas, R. Collot, J. Yang, K. Harvey, M. Z. Johan, C. Cooper, R. Nair, D. Herrmann, A. McFarland, , A. Swarbrick

This study identifies Hedgehog signaling to cancer-associated fibroblasts as a driver of cancer stem cell plasticity and chemoresistance in TNBC, showing that targeting this pathway with smoothened inhibitors improves survival in preclinical models and clinical trials.

bioRxiv · Nov 8, 2017Cancer Biology