S. Paessler

Inhibitors of cannabinoid receptor 1 suppress the cellular entry of Lujo virus

This study identifies CB1 receptor antagonists as inhibitors of Lujo virus entry by suppressing viral membrane fusion and reducing infectivity in vitro.

Lassa virus NP DEDDh 3'-5'exoribonuclease activity is required for optimal viral RNA replication and mutation control.

This study shows that Lassa virus NP ExoN is essential for viral RNA replication and mutation control, highlighting a new role for this protein beyond immune evasion.

Ehrlichia SLiM ligand mimetic activates Hedgehog signaling to engage a BCL-2 anti-apoptotic cellular program

This study identifies a TRP120 SLiM ligand mimetic from Ehrlichia chaffeensis that activates Hedgehog signaling to induce BCL-2 expression and inhibit apoptosis, facilitating bacterial infection.

Ehrlichia SLiM ligand mimetic activates Notch signaling in human monocytes

This paper identifies a short linear motif (SLiM) in the Ehrlichia TRP120 effector that mimics Notch ligands to activate Notch signaling in human monocytes.

Machupo virus with mutations in the transmembrane domain and glycosylation sites is attenuated and immunogenic in animal models of Bolivian Hemorrhagic Fever

This paper attenuates Machupo virus by mutating glycosylation sites and a transmembrane domain residue, showing attenuation in animal models and protective efficacy against wild-type virus.

Catch and kill airborne SARS-CoV-2 to control spread of COVID-19 by a heated air disinfection system

Heated Ni-foam filters effectively catch and kill airborne SARS-CoV-2 and Bacillus anthracis spores.

Protective Effects of STI-2020 Antibody Delivered Post-Infection by the Intranasal or Intravenous Route in a Syrian Golden Hamster COVID-19 Model

This study evaluates the efficacy of STI-2020 antibody delivered post-infection via intranasal or intravenous routes in a hamster model of COVID-19, showing reduced disease severity and duration.

Discovery and Development of Human SARS-CoV-2 Neutralizing Antibodies using an Unbiased Phage Display Library Approach

This study identifies and develops human SARS-CoV-2 neutralizing antibodies using a phage display library, showing their efficacy in vivo against the virus.

The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines

This paper evaluates PTC299's ability to inhibit SARS-CoV-2 replication and reduce inflammatory cytokine production in tissue culture models.

Efficacy of a novel iodine complex solution, CupriDyne, in inactivating SARS-CoV-2

This study evaluates the efficacy of CupriDyne, a novel iodine complex, in inactivating SARS-CoV-2, showing 99% reduction in virus titers after 30 minutes.

The IMPDH inhibitor merimepodib suppresses SARS-CoV-2 replication in vitro.

This study shows that the IMPDH inhibitor merimepodib suppresses SARS-CoV-2 replication in vitro by reducing viral titers by up to 4 logs after overnight pretreatment.

Potent Antiviral Activities of Type I Interferons to SARS-CoV-2 Infection

This study shows that Type I interferons significantly reduce SARS-CoV-2 viral titers in Vero cells, with IFN-β being more effective than IFN.