Molecular basis for Gβγ-mediated activation ofphosphoinositide 3-kinase γ
C.-l. Chen, R. Syahirah, S. Ravala…·J. J. G. Tesmer
This study identifies two distinct Gβγ binding sites on PI3Kγ and shows how Gβγ activates the enzyme through conformational changes and allosteric control.