J. Pei

A rewiring of the earliest immune events leading to T-cell mediated disease following intestinal infection in a PINK1 knock out mouse model of Parkinsons disease

This study identifies early immune dysregulation in PINK1 KO mice following intestinal infection, showing myeloid cell activation and T cell response as key factors in PD-like disease progression.

Identification of Candidate Diagnostic gene CDC25C for Trametinib-induced Cardiotoxicity by Integrating Bioinformatics and Machine Learning

Essential and virulence-related protein interactions of pathogens revealed through deep learning

This study uses deep learning to predict protein-protein interactions in bacterial pathogens, identifying new complexes involving essential genes and virulence factors, with half of tested predictions validated.

COA8 is a COX10-binding protein involved in the early biogenesis of cytochrome c oxidase

This study identifies COA8 as a COX10-binding protein essential for COX10 stability and catalytic activity in human cytochrome c oxidase biogenesis.

Modeling gene-environment interactions in Parkinson's Disease: Helicobacter pylori infection of Pink1-/- mice induces CD8 T cell-dependent motor and cognitive dysfunction.

This study shows that Helicobacter pylori infection in Pink1-/- mice causes motor and cognitive dysfunction linked to CD8 T cell activity, mimicking early PD features.

Identification and Characterization of CtUGT3 as the Key Player of Astragalin Biosynthesis in Safflower

This study identifies CtUGT3 as the key UGT enzyme responsible for astragalin biosynthesis in safflower through metabolomics, transcriptome analysis, and biochemical experiments.

Single-cell RNA-sequencing identifies a novel subset of CD9+ reparative macrophages modulated by CCN2 derived from Nlrx1 deficient cardiomyocytes in the infarcted heart

The paper identifies a novel CD9+Il1rn+ reparative macrophage subset in infarcted hearts modulated by CCN2 from Nlrx1-deficient cardiomyocytes, showing potential therapeutic implications for myocardial healing.

Piperlongumine (PL) conjugates induce targeted protein degradation

The paper identifies piperlongumine as a covalent E3 ligase recruiter that, when conjugated with CDK9 inhibitors, induces targeted protein degradation of CDK9 and EML4-ALK fusion oncoprotein.

Structures of core eukaryotic protein complexes

The paper uses coevolution analysis and deep learning to model core eukaryotic protein complexes in yeast, identifying 104 new assemblies and structurally characterizing 608 previously unknown complexes.

TMEM120 is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase

The paper presents the cryo-EM structure of TMEM120A, revealing it binds coenzyme A and shares structural features with ELOVL fatty acid elongase, suggesting a potential role in fatty acid metabolism rather than mechanosensation.

Small Molecule Stabilization of PINK-1/PINK1 Improves Neurodegenerative Disease

The paper screens small molecules to activate mitophagy, identifies two compounds that reduce neurodegenerative disease phenotypes in C. elegans.

Exposure to hypergravity during development leads to altered cartilage material properties and strain distribution in zebrafish.

This study shows that exposing zebrafish to hypergravity during development alters jaw cartilage mechanical properties and strain distribution, with associated changes in chondrocyte morphology.

A tractable Drosophila cell system enables rapid identification of Acinetobacter baumannii host factors

This study uses Drosophila S2 cells to identify host factors and mechanisms involved in Acinetobacter baumannii intracellular survival and persistence.

CLADES: A Classification-based Machine Learning Method for Species Delimitation from Population Genetic Data

CLADES uses machine learning to delimit species from population genetic data, showing accuracy and efficiency compared to existing methods, especially in cases with short divergence times and gene flow.