K. Das

Structural insights into transcription regulation of the global virulence factor PhoP from Mycobacterium tuberculosis

This study determines cryo-EM structures of PhoP-dependent transcription complexes in Mtb to elucidate its dual role as activator and repressor in stress adaptation.

The dependence of shugoshin on Bub1-kinase activity is dispensable for the maintenance of spindle assembly checkpoint response in Cryptococcus neoformans

This study shows that Sgo1 maintains SAC signals in Cryptococcus neoformans by regulating Aurora B kinase and PP1 levels at kinetochores, independent of Bub1 kinase activity.

Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia

This study identifies GNASR201C as a driver of pyloric metaplasia in IPMN, characterized by tumor-suppressive glycans that inhibit cancer progression.

Dissociable contributions of basolateral amygdala and ventrolateral orbitofrontal cortex to flexible learning under uncertainty

This study investigates the distinct roles of vlOFC and BLA in stimulus- and action-based reversal learning under uncertainty using chemogenetic inhibition in rats.

BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor

This study shows that FHD-286, a BRG1/BRM inhibitor, reduces AML burden and improves survival when combined with Menin or BET inhibitors in xenograft models of AML with MLL1r or mtNPM1.

An inimitable proprotein convertase subtilisin kexin-9 (PCSK9) cleavage site VFAQ on Spike protein along with furin cleavage site makes SARS-CoV-2 unique

The paper identifies a novel PCSK9 cleavage site in SARS-CoV-2 Spike protein and suggests its combination with the furin site contributes to the virus's uniqueness in pathogenicity and drug development.

Intramuscular mRNA BNT162b2 vaccine against SARS-CoV-2 induces robust neutralizing salivary IgA

This study shows that the BNT162b2 mRNA vaccine induces temporary salivary IgA with strong neutralizing activity against SARS-CoV-2.

Structural insights into TRAP association with ribosome-Sec61 complex, and translocon inhibition by a CADA derivative

The paper presents cryo-EM structures of the ribosome-Sec61 complex with TRAP and CK147, showing TRAP's binding and CK147's inhibition mechanism.

Yeast mtDNA transcription initiation in single nucleotide addition steps

This study reports cryo-EM structures of yeast mitochondrial RNA polymerase initiation complexes, revealing the stepwise process of transcription initiation and the role of structural changes in RNA synthesis.

Mitochondrial Derived Vesicles retain membrane potential and contain a functional ATP synthase

The paper isolates and characterizes Mitochondrial Derived Vesicles (MDVs) from yeast, showing they contain functional ATP synthase and membrane potential, suggesting a role in organelle communication.

Ubiquitination occurs in the mitochondrial matrix byeclipsed targeted components of the ubiquitin machinery

The paper demonstrates that ubiquitination occurs in yeast mitochondrial matrix using components of the ubiquitin machinery, independent of cytosolic proteasome activity.

Cryo-EM structures of Doravirine and Rilpivirine with HIV-1 Reverse Transcriptase/DNA Aptamer: Nonnucleoside Inhibitor Resistance by E138K and M184I Mutations

The paper determines cryo-EM structures of HIV-1 reverse transcriptase with nonnucleoside inhibitors, revealing structural changes due to resistance mutations.

Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket - Targeting P-pocket by fragment screening

The paper identifies a transient P-pocket in HIV-1 reverse transcriptase during DNA sliding and demonstrates fragment screening to target this pocket for inhibitor development.

3'-Sulfated Lewis A is a Biomarker for Metaplastic and Oncogenic Transformation of Several Gastrointestinal Epithelia

This study identifies 3-Sulfo-Lewis A as the epitope recognized by the antibody Das-1, which is reexpressed in metaplastic and carcinomatous gastrointestinal lesions.

Crystal Structure of a Retroviral Polyprotein:Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT)

This paper reports the crystal structure of prototype foamy virus protease-reverse transcriptase (PR-RT), revealing its monomeric architecture and domain organization compared to HIV-1 enzymes.

Unique features of stimulus-based probabilistic reversal learning

This study compares discrimination and reversal learning in rats, finding distinct behavioral patterns and differences in reward sensitivity and learning rates between the two tasks.

Sex-dependent effects of chronic intermittent voluntary alcohol consumption on attentional, not motivational, measures during probabilistic learning and reversal

This study examines sex-dependent effects of voluntary alcohol consumption on attentional measures during probabilistic learning and reversal in rats, finding increased vulnerability in females.

Cryo-EM structures reveal transcription initiation steps by yeast mitochondrial RNA polymerase

The paper uses cryo-EM to reveal steps of transcription initiation by yeast mitochondrial RNA polymerase, including promoter melting, template alignment, and abortive synthesis mechanisms.

Visual processing and attention rather than face and emotion processing play a distinct role in ASD: an EEG study

This study uses EEG to show that early visual processing and attention, not face or emotion processing, are key in distinguishing ASD from typically developing individuals.

Rat bone marrow derived mesenchymal stem cells differentiate to germ cell like cells

This study shows rat bone marrow-derived mesenchymal stem cells can differentiate into male germ cell-like cells in vitro, offering potential for fertility research and therapeutic applications.