V. Gama

Patient mutations in DRP1 perturb synaptic maturation of cortical neurons

This study shows that DRP1 mutations disrupt synaptic maturation in cortical neurons by altering mitochondrial morphology and calcium dynamics.

Leptomeningeal Neural Organoid (LMNO) Fusions as Models to Study Meninges-Brain Signaling

The paper develops a co-culture model of human iPSC-derived neural organoids fused with mouse leptomeninges to study meninges-brain signaling and assesses its stability and utility.

Functional Overlap of Inborn Errors of Immunity and Metabolism Genes Define T Cell Immunometabolic Vulnerabilities

The paper identifies functional overlap between inborn errors of immunity and metabolism genes, revealing immunometabolic vulnerabilities in T cells.

Radiation-Induced Autophagy Regulates the Fibroblast Mitochondrial Stress Response and Crosstalk with Triple-Negative Breast Cancer Cells

This study shows that radiation-induced autophagy in fibroblasts alters their mitochondrial stress response, promoting an aggressive phenotype in triple-negative breast cancer cells.

DRP1-mediated mitochondrial fission is essential to maintain cristae morphology and bioenergetics

This study investigates how DRP1 mutations affect mitochondrial and peroxisomal dynamics, leading to metabolic dysfunction and structural abnormalities in EMPF1 patient fibroblasts.

Apoptotic Find-me Signals are an Essential Driver of Stem Cell Conversion To The Cardiac Lineage

This study shows that apoptotic signals drive stem cell conversion to the cardiac lineage through nucleotide-mediated paracrine signaling during mesoderm specification.

Human iPSC-derived cerebral organoids model features of Leigh Syndrome and reveal abnormal corticogenesis

This study uses iPSC-derived cerebral organoids to model Leigh Syndrome, identifying defects in brain development and mitochondrial morphology.

MCL-1 inhibition by selective BH3 mimetics disrupts mitochondrial dynamics in iPSC-derived cardiomyocytes

This study shows that MCL-1 inhibition by BH3 mimetics disrupts mitochondrial dynamics and function in iPSC-derived cardiomyocytes, suggesting a non-apoptotic role for MCL-1 in cardiac health.

Spin{infty} an improved miniaturized spinning bioreactor for the generation of human cerebral organoids from pluripotent stem cells

The paper introduces a new miniaturized bioreactor, Spin{infty}, designed to improve the stability and reduce contamination risks in generating human cerebral organoids from pluripotent stem cells.

Precise tuning of cortical contractility regulates cell shape during cytokinesis

This study shows that balancing MII paralogs fine-tunes polar cortex tension to maintain cell shape during cytokinesis.

Sox6: A new modulator of renin expression during physiological conditions

This study identifies Sox6 as a regulator of renin expression in juxtaglomerular cells during physiological and pathophysiological conditions.