V. Kumar

The paper develops a SILAC-based MIB-MS workflow to profile the kinome in endometrial tumors, identifying SRPK1 as a potential therapeutic target.

This study identifies OPR3 as a bifunctional enzyme with roles in detoxification and redox homeostasis by reducing electrophilic species and regenerating ascorbate.

This study shows that human mesenchymal stem cells migrate from high to low loss modulus in response to viscous gradients, termed 'viscotaxis', and identifies cellular traction as the mechanism.

This study shows that phosphorylation of VP35 Ser129 modulates its functions, uncoupling interferon inhibition from replication, and identifies it as a potential therapeutic target.

This study identifies a 6 Mb polymorphism desert region on chromosome 5 associated with grain size/weight QTL and shows it is an evolutionary important site linked to domestication traits.

This study identifies how HSV's ICP0 protein uses phosphorylation by Chk2 to activate its SUMO-targeted Ubiquitin Ligase activity against PML NBs.

This study investigates how stabilizing mutations in Bacillus subtilis lipase affect protein dynamics and stability, finding that enhanced dynamics in certain regions can improve overall stability without reducing activity.

The paper investigates the structural and functional impact of non-synonymous SNPs in the TEN1 gene using computational tools to identify deleterious mutations and their effects on protein stability and function.

This study shows ELYS regulates NF-κB pathway dynamics during Drosophila development, and its misregulation causes apoptosis through sustained NF-κB nuclear accumulation.

This paper develops a neural network-based mouse tracker for complex environments, finding that an encoder-decoder segmentation model achieves high accuracy with minimal training data.

This paper shows that culturing human mesenchymal stem cells on soft polyacrylamide gel maintains their stemness by delaying senescence compared to traditional tissue culture plates.

The paper generates high-spatial-resolution transcriptome data from Populus tremula wood-forming tissues and identifies novel gene modules and expression patterns involved in cambial growth and wood formation.

This study analyzes bear genomes to show that gene flow across species is common and not limited to closely related species, challenging traditional speciation models.