J. Kumar

Rapalink-1 reveals novel mTOR-dependent genes and an agmatinergic axis-based metabolic feedback regulating mTOR activity and lifespan

This study shows that rapalink-1, a mTOR inhibitor, extends lifespan in fission yeast by modulating an agmatinergic metabolic feedback circuit that regulates mTOR activity.

P66Shc Mediates SUMO2-induced Endothelial Dysfunction

This study identifies SUMO2-mediated modification of p66Shc as a mechanism causing endothelial dysfunction and oxidative stress in hyperlipidemia.

Analytical Method Development for Evaluation of Pharmacokinetics and Tissue Distribution of Thiourea-Based Antivirals through nLC/MS-MS

The paper develops a sensitive nLC-MS/MS method to quantify thiourea derivatives in plasma and tissues of rats, showing good linearity and precision.

Safety Assessment and Evaluation of Novel Thiourea Derivatives as Antivirals

This paper evaluates the safety of three thiourea derivatives (DSA-00, DSA-02, DSA-09) as antivirals, finding they are non-cytotoxic, non-mutagenic, and have moderate acute toxicity.

Leveraging RAS-mSIN1 Interaction to Selectively Inhibit mTORC2 Employing Competitive RAS Binding Peptide: Implications in Breast Cancer Metastasis

The paper withdraws a manuscript due to incomplete experiments and requests that it not be cited as a reference.

Efficient protein tagging and cis-regulatory element engineering via precise and directional oligonucleotide-based targeted insertion in plants

This study improves targeted insertion in plants using chemically protected dsODNs with 5' 1-nt overhangs, achieving directional and precise insertions for gene tagging and cis-regulatory engineering in Setaria viridis and rice.

Automatic Abdominal Multi Organ Segmentationusing Residual UNet

This paper develops a residual UNet model for abdominal multi-organ segmentation using CT and MRI scans, achieving high Dice scores in held-out tests.

Automatic Whole Body FDG PET/CT Lesion Segmentation using Residual UNet and Adaptive Ensemble

The paper develops a deep learning method using residual UNET and adaptive ensemble for automated FDG PET/CT lesion segmentation, achieving a dice score of 0.5541 on a test dataset.

Dissecting the cell cycle regulation, DNA damage sensitivity and lifespan effects of caffeine in fission yeast

This study investigates how caffeine affects cell cycle regulation, DNA damage sensitivity, and lifespan in fission yeast by modulating the AMPK pathway.

An Extensible Vector Toolkit and Parts Library for Advanced Engineering of Plant Genomes

The paper introduces a Golden Gate cloning toolkit and Phytobrick library to streamline plant genome engineering, enabling complex T-DNA assembly and improved expression analysis.

Knowledge production and translation of science between Academia and Industry: assessing the impact of R&D in India

This study analyzes the factors influencing patent filings in India and highlights the importance of academia-industry collaboration for translating research into industrial output.

Composite modeling of leaf shape across shoots discriminates Vitis species better than individual leaves

The paper models leaf shape changes across shoots in Vitis species and finds composite leaves better predict species identity than individual leaves.

CASSPER: A Semantic Segmentation based Particle Picking Algorithm for Single Particle Cryo-Electron Microscopy

CASSPER automates protein particle detection in cryo-EM images using semantic segmentation, eliminating manual picking and improving detection in variable ice conditions.

The Architecture of GluD2 Ionotropic Delta Glutamate Receptor Elucidated by cryo-EM

This study determines the cryo-EM structure of the rat GluD2 receptor, revealing its unique 3D architecture and differences from GluD1.

Structural Insights into GluK3-kainate Receptor Desensitization and Recovery

The paper determines structural changes in GluK3-kainate receptors during desensitization and recovery using cryo-EM, revealing domain rearrangements and the role of N-linked glycans in receptor function.