RAPSYN-Mediated Neddylation of BCR-ABL Alternatively Determines the Fate of Philadelphia Chromosome-positive Leukemia
m. Zhao, B. Dai, X. Li, Y. Zhang, C. Qiao, Y. Qin, Z. Li, Q. Li, S. Wang, Y. Yang, Y. Chen
This study identifies RAPSYN-mediated neddylation of BCR-ABL as a mechanism driving Ph+ leukemia progression and presents it as a therapeutic target.
bioRxiv · May 24, 2023Cancer Biology