Author

Y. Deguchi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

D. Wei· 3 shared F. Liu· 3 shared I. Shureiqi· 3 shared X. Zuo· 3 shared Y. Liu· 3 shared B. Wei· 2 shared L. A. Valentin· 2 shared M. J. Moussalli· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

D. Wei

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4 papers

Recent·Most cited

Colorectal ALOX15 as a host factor determinant of EPA and DHA effects on colorectal carcinogenesis

X. Zuo, Y. Kiyasu, Y. Liu, Y. Deguchi, F. Liu, M. Moussalli, L. Tan, B. Wei, D. Wei, P. Yang, I. Shureiqi

This study shows that ALOX15 expression modulates EPA and DHA effects on colorectal carcinogenesis by promoting resolvin generation, which suppresses pro-tumorigenic inflammation.

bioRxiv · May 2, 2024 · PreprintCancer Biology

Ppard Is Essential in Acceleration of Pancreatic Ductal Adenocarcinoma Development by High-Fat Diet in Mutant Kras Mice

Y. Liu, Y. Deguchi, D. Wei, M. J. Moussalli, D. Li, H. Wang, L. A. Valentin, J. K. Colby, F. Liu, J. Wang, X. Zheng, B. Ji, J. C. Yao, X. Zuo, I. Shureiqi

This study shows that PPARD promotes pancreatic ductal adenocarcinoma in mutant Kras mice on high-fat diets, and its inhibition could be a therapeutic strategy.

bioRxiv · Dec 4, 2020 · PreprintCancer Biology

Interleukin-11 is a Marker for Both Cancer- and Inflammation-Associated Fibroblasts that Contribute to Colorectal Cancer Progression

T. Nishina, Y. Deguchi, W. Takeda, M. Ohtsuka, D. Ohshima, S. Yamazaki, M. Kawauchi, E. Nakamura, C. Nishiyama, Y. Kojima, S. Adachi-Akemi, M. Hasegawa, M. Nakayama, M. Ohshima, H. Yagita, , H. Nakano

This study identifies IL-11 as a marker for fibroblasts involved in colorectal cancer progression, showing their role in tumor development through a feed-forward loop.

bioRxiv · Jan 25, 2020 · PreprintCancer Biology

Suppression of membranous LRP5 recycling, WNT/β-catenin signaling, and colorectal tumorigenesis by 15-LOX-1 peroxidation of PI3P_linoleic acid

F. Liu, X. Zuo, Y. Liu, Y. Deguchi, M. J. Moussalli, W. Chen, P. Yang, B. Wei, P. L. Lorenzi, S. Gao, J. C. Jaoude, A. Mehdizadeh, L. A. Valentin, D. Wei, I. Shureiqi

This study shows that 15-LOX-1 metabolism of LA in PI3P reduces LRP5 membrane levels, inhibits Wnt/β-catenin signaling, and suppresses colorectal tumorigenesis in mice.

bioRxiv · Aug 29, 2019Cancer Biology