Evolutionary BiologybioRxiv
Exploring the mutational robustness of nucleic acidsby searching genotype neighbourhoods in sequencespace
Q. Zhou, X. Sun, X. Xia…·E. Shakhnovich
The paper uses in silico SELEX to study mutational robustness of an L-Arm binding aptamer, finding two functional genotype neighborhoods with similar binding affinity to the wild-type.
DOI 10.1021/acs.jpclett.6b02769