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This study shows that maternal high-fat diet during gestation and lactation leads to systemic inflammation and altered gut-brain axis function in male offspring through disrupted tight junctions and reduced satiety peptides.

This study shows that postpartum resource scarcity in rats alters maternal behavior, offspring prioritization, and steroid-sensitive brain region structure.

This study identifies early proteomic changes in cardiac fibroblasts after doxorubicin treatment, revealing ECM and mitochondrial-related proteins associated with early senescence responses.

This study compares HIV-1 gp120 subtypes A and B, showing subtype A induces more severe pulmonary arterial hypertension through enhanced furin activity and different CD4 and nAChR interactions.

This paper uniformly re-analyzes public omics data from exercise studies in humans and rodents, providing standardized effect sizes and meta-analyses across multiple tissues and molecular layers.

This study shows that dual inhibition of MLK3 and LRRK2 with URMC-099 reduces PD pathology and motor deficits in an AAV-haSyn rat model.

This study links ER stress and impaired NAD biosynthesis via QPRT to reduced oocyte quality and shows that NMN supplementation improves oocyte function and early embryonic development.

This study shows that intestinal epithelial stem cell secretome improves gut repair and cognitive outcomes after stroke in male rats but not in female rats, highlighting the need for sex-specific therapies.

This study identifies inosine triphosphate pyrophosphatase (ITPA) as a candidate factor linking chronic heart failure and white matter abnormalities through human, animal, and cellular analyses.

The paper identifies germ granule-like amyloid/RNA condensates in rat epididymal spermatozoa that exhibit prion-like propagation activity, suggesting a non-Mendelian mechanism for transmitting environmental information to offspring.

This study compares somitogenesis across human, pig, sheep, and cow stem cell-derived embryo models, revealing species-specific WNT signaling and extracellular matrix requirements for axial segmentation.

This study shows imipramine binds to amyloid-β, reduces Aβ accumulation, and improves survival in Alzheimer's patients.

This study shows that targeted degradation of long PDE4D isoforms reduces cardiac hypertrophy without affecting contractile function in rat and human cardiomyocytes.

This paper introduces NORIGAMI, a multi-omics pipeline that combines imaging and deep learning to analyze kidney aging, revealing age-related structural and molecular changes.

This study examines how PFOS and GenX affect mitochondrial respiratory complex activities in liver and brain tissues under different exposure conditions, showing exposure-dependent and tissue-specific effects.

This study identifies Vago4 as a ligand that downregulates Domeless to restrain JAK/STAT signaling in invertebrates, defining an IFN-like axis.

This study shows that KIF1A-mediated lysosomal transport into axons is regulated by the axon initial segment microtubule environment, and its disruption leads to axonal degeneration.

The paper compares brain and kidney extracellular vesicle morphology and proteomics after inflammatory challenge, identifying significant protein changes but noting limitations in causal conclusions.

This study shows that neuronal hyperactivity selectively increases tau phosphorylation at S202/T205 in excitatory hippocampal neurons, which reduces GluA2 surface expression and may contribute to Alzheimer's disease pathology.

The paper shows that early clonal dominance in B-cell precursors after vaccination predicts the breadth of HIV-neutralizing antibodies in rhesus macaques.

This study identifies early innate immune signatures following Ad26.COV2.S vaccination that correlate with vaccine durability and protective efficacy in rhesus macaques and humans.

This study investigates how Tpm3.1 stabilizes cortical F-actin in chondrocytes and how its loss drives catabolic gene expression through YAP and MRTF.

This study identifies ROR2 as a driver of right ventricular failure by disrupting proteostasis, showing that modulating ROR2 can rescue structural and functional deficits in cardiomyocytes.

This study investigates how erythrocyte extravasation contributes to skeletal muscle injury via the heme-HO-1-iron axis, linking it to ferroptosis and inflammation.

The paper investigates whether genetically diverse B-cell receptor responses in simian-HIV infected macaques converge functionally, finding that functional convergence does not require genetic convergence.

This study identifies a bidirectional pathogenic relationship between alpha-synuclein and neuromelanin in Parkinson's disease, showing they promote each other's accumulation and neuronal loss.

This study examines how hypoxia and inflammation affect skeletal muscle mitochondrial function and protein turnover in different muscle types, finding muscle-specific responses and physiological variability.

PlasmoRhythm integrates time-resolved omics data from malaria parasites, hosts, and vectors to enable comparative analysis of rhythmic molecular profiles.

This study shows that a nine-phthalate mixture causes dose-additive fetal testis toxicity in rats, including MNGs and reduced testosterone, with the lowest effective dose for MNGs.

The paper annotates CAZymes in five parasitic trichomonads, identifying 1,406 genes and revealing conserved mucin O-glycan-targeting and antibacterial CAZyme toolkits.