Cardiac electrophysiology and arrhythmias

The paper uses human-based modeling to evaluate cell therapy in acute and chronic myocardial infarction, finding that cell heterogeneity and Purkinje system function influence arrhythmia risk.

This paper develops a computational pipeline to calibrate iPSC-CM electrophysiological models using optical experiments, improving parameter estimates and model predictions of unseen responses.

This study identifies TMPRSS6 cleavage of KCNE1 as a mechanism causing arrhythmias in iron overload disease using human iPSC-derived cardiomyocytes and computational models.

The paper identifies a de novo enhancer mutation in KCNB1 causing ST Depression Syndrome, a cardiac arrhythmia, and shows it can be predicted by a deep neural network.

This study identifies an upstream alternative polyadenylation event in SCN5A that generates a short transcript encoding a mitochondria-localized NaV1.5 N-terminal fragment, which affects cardiomyocyte respiration.

This paper develops an atrial-specific in-silico model of stem cell-derived cardiomyocytes integrating IKur and IKCa currents, validated against experimental data to improve drug testing and understanding of atrial fibrillation.

This study shows that IP3R activation in atrial myocytes increases cAMP, which can be inhibited by IP3R blockers, but ventricular myocytes show cAMP increases independent of IP3R.

This paper shows Salidroside reduces malignant arrhythmias in AMI by restoring sodium channel function and improving conduction uniformity.

This study shows that a polygenic risk score for QTc (PRSQTc) predicts increased QTc interval and short-term mortality in patients starting QT-prolonging medications.

The paper models how calcium current reduction in cardiomyocytes at the left pulmonary vein outlet can lead to persistent re-entry waves, contributing to atrial fibrillation progression.

The paper evaluates five mathematical models of cardiac tissue to assess their computational efficiency and physiological accuracy for different tissue sizes and resolutions.

This study investigates sympathetic remodeling in rabbit hearts after reperfused myocardial infarction, finding CSPGs correlate with reduced nerve density but preserved sympathetic responsiveness, leading to increased arrhythmia risk.

The paper validates an in vitro SCN5A Brugada Syndrome assay to reclassify variants of uncertain significance as pathogenic or benign.

This study investigates the anti-arrhythmic effects of thoracic epidural blockade after myocardial infarction, finding it reduces ventricular tachyarrhythmia inducibility and improves parasympathetic function.

The paper identifies proteostasis interactomes of trafficking-deficient KV11.1 variants and shows pharmacological chaperone rescue of proteostasis network alterations in LQTS-associated variants.

This study examines electroanatomical changes in guinea pig hearts from neonatal to adult stages, finding age-related differences in conduction velocity, action potential duration, and excitation-contraction coupling.

The paper develops a computational pipeline to create digital twins of cardiac electrophysiology for pediatric congenital heart disease patients using BLNMs to match clinical ECGs.

This study identifies S100A1's C85 residue as a redox-switch critical for preventing diastolic calcium leakage in cardiomyocytes, without affecting inotropic function.

This study identifies barriers to genetic testing in cardiac care by surveying providers, finding insurance issues and specialty differences affect testing uptake.

This study uses computational modeling to show that interdigitated structures between pacemaker and atrial cells enhance electrical pulse propagation when protrusions are of sufficient size and synchronized.

This study investigates how the PLN R9C mutation affects iPSC-CMs and shows that promoting autophagy can mitigate stress-induced structural and functional defects in these cells.

This study uses an in silico cardiomyocyte model to show that HCM leads to impaired crossbridge kinetics and a negative ATP supply-demand mismatch.

This study identifies that RyR2 mutation locations in CPVT patients predict earlier onset of sudden death, based on a meta-analysis of 1008 patients from 227 papers.

This study shows that TRPA1 activation and disrupted repolarisation-relaxation coupling during systole contribute to mechano-arrhythmogenesis in ischaemic conditions.

The paper demonstrates that cardiac myocyte T-tubules can generate action potentials autonomously, distinct from those in the sarcolemma, using an all-optical method.

The paper identifies a novel SCN5A variant, E171Q, that creates a gating pore current by neutralizing a negative charge in the S2 helix, leading to MEPPC and altered voltage dependence.

The paper shows that male sex hormones and reduced plakoglobin impair atrial conduction and sodium currents in mice, contributing to atrial remodelling.

This study identifies transcriptomic changes in the sinoatrial node of mice overexpressing AC8, revealing altered pathways and transcription factors linked to cardiac aging and disease.