Discover, rate, and discuss biology preprints.
363,000+ bioRxiv and medRxiv preprints, including those later published in peer-reviewed journals, across 26 biological disciplines.
Recent preprints
- PathologybioRxiv
Combined abdominal heterotopic heart and aorta transplant model in mice
H. Dun, L. Ye, Y. Zhu, B. W. Wong
This paper develops a combined abdominal heart and aorta transplant model in mice to study allograft vasculopathy and immunosuppressive strategies.
DOI 10.1371/journal.pone.0230649 - PathologybioRxiv
Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease
G. Wu, Y. Y. Lee, E. M. Gulla…·D. F. Smith
This study shows that intermittent hypoxia in mice alters gene expression in lung cells, particularly in endothelial cells, linking it to pulmonary fibrosis and hypertension pathways.
DOI 10.7554/elife.63003 - PathologybioRxivPreprint
Epizootic of highly pathogenic H7N3 Avian Influenza in an ecologic reserve in Mexico.
H. E. Valdez-Gomez, R. Navarro-Lopez, M. Solis-Hernandez…·C. L. Afonso
The paper describes an epizootic of H7N3 avian influenza in an ecologic reserve in Mexico and evaluates control measures to contain the outbreak.
DOI 10.1101/2020.03.05.978502 - PathologybioRxivPreprint
Tracking the outbreak. An optimized delimiting survey strategy for Xylella fastidiosa.
E. Lazaro, M. Sese, A. Lopez-Quilez…·A. Vicent
The paper develops and implements an optimized sequential adaptive delimiting survey strategy for Xylella fastidiosa outbreaks, improving efficiency by adapting sampling intensity based on spatial resolution.
DOI 10.1101/2020.03.05.978668 - PathologybioRxiv
A comprehensive proteomic SWATH-MS workflow for profiling blood extracellular vesicles: a new avenue for glioma tumour surveillance
S. Hallal, A. Azimi, H. Wei…·K. L. Kaufman
This study uses SWATH-MS to comprehensively profile plasma extracellular vesicles from glioma patients, identifying potential biomarkers that reflect glioma subtype and aggressiveness.
DOI 10.3390/ijms21134754 - PathologybioRxiv
Comparative analysis of biological aspects of Leishmania infantum isolates
T. Paes, K. d. S. Charret, M. R. d. S. Ribeiro…·L. L. Leon
This study compares the biological and molecular differences between Leishmania infantum infantum and L. infantum chagasi strains, finding differences in infectivity and enzyme activity despite genetic similarity.
DOI 10.1371/journal.pone.0230545 - PathologyEar & HearingPeer-reviewed
Improving Sensitivity of the Digits-in-Noise Test using Antiphasic Stimuli
K. C. De Sousa, D. W. Swanepoel, D. R. Moore…·C. Smits
This paper introduces antiphasic digit presentation in the digits-in-noise test, showing improved sensitivity to various hearing losses compared to traditional monaural or diotic methods.
DOI 10.1097/aud.0000000000000775 - PathologybioRxivPreprint
ABO blood group, glycosyltransferase activity and risk of Venous Thrombosis
M. IBRAHIM-KOSTA, P. Bailly, M. SILVY…·L. Goumidi
This study shows that glycosyltransferase (GT) activities are lower in venous thrombosis (VT) patients compared to controls with the same ABO blood group, but the relationship with VWF/FVIII levels is only significant in B blood group carriers.
DOI 10.1101/2020.03.01.971754 - PathologybioRxiv
Post-traumatic osteoarthritis development is not modified by postnatal chondrocyte deletion of CCN2.
C. Keenan, L. Ramos-Mucci, I. Kanakis…·B. Poulet
This study shows that deleting CCN2 in adult chondrocytes does not alter the development of post-traumatic osteoarthritis in mice.
DOI 10.1242/dmm.044719 - PathologybioRxivPreprint
Causes of death in newborn C57BL/6J mice
S. C. Peneda, G. M. Morello, S. Lamas…·C. Gilbert
This study investigates causes of death in newborn C57BL/6J mice, finding that starvation was the most common cause, followed by stillbirth.
DOI 10.1101/2020.02.25.964551 - PathologybioRxiv
Clinical Epidemiology of congenital heart diseases in dogs: prevalence, popularity and volatility throughout twenty years of clinical practice
P. G. Brambilla, M. Polli, D. Pradelli…·C. Bussadori
This study examines the epidemiology of congenital heart diseases in dogs over 20 years, finding that breed-specific screening reduced disease prevalence but trends and popularity influence breeding choices more than health concerns.
DOI 10.1371/journal.pone.0230160 - PathologybioRxivPreprint
Whole Slide Preview Image Segmentation and Setup for Digital Pathology Scanners
M. S. Hosseini, D. Lee, D. Gershanik…·K. N. Plataniotis
This paper introduces pipelines for automating tissue preview segmentation in digital pathology scanners using brightfield and darkfield microscopy.
DOI 10.1101/2020.02.24.963645 - PathologybioRxivPreprint
An original structural fold underlies the multitask P1, a silencing suppressor encoded by the Rice yellow mottle virus
V. Poignavent, F. Hoh, G. Terral…·F. Vignols
The paper determines the 3D structure and dynamics of P1, a silencing suppressor from Rice Yellow Mottle virus, revealing structural features and their roles in viral infectivity.
DOI 10.1101/2020.02.24.963488 - PathologybioRxivPreprint
Muscle progenitor cells are required for the regenerative response and prevention of adipogenesis after limb ischemia
H. Abbas, L. A. Olivere, M. E. Padgett…·C. D. Kontos
This study shows that Pax7+ muscle progenitor cells are essential for muscle regeneration and preventing adipogenesis after limb ischemia, with implications for treating peripheral artery disease.
- PathologybioRxivPreprint
Intra-abdominal resection of the umbilical vein and urachus of bovine fetuses using videolaparoscopy and celiotomy: surgical time and feasibility (cadaveric study)
F. D. O. Monteiro, H. J. Gurgel, S. S. de Sousa…·P. P. M. Teixeira
This study compares the feasibility and surgical time of videolaparoscopy and celiotomy for resecting umbilical vein and urachus in bovine fetuses, finding laparoscopy faster with less tissue damage.
DOI 10.1101/2020.02.24.962431 - PathologybioRxiv
Visualizing ultrastructural details of placental tissue with super-resolution structured illumination microscopy
L. E. Villedgas-Hernandez, M. Nystad, F. Strohl…·B. S. Ahluwalia
The paper describes sample preparation and acquisition parameters for super-resolution structured illumination microscopy (SIM) of placental tissue and demonstrates its ability to resolve ultrastructural details previously only visible with electron microscopy.
- PathologybioRxivPreprint
Pangolin homology associated with 2019-nCoV
The paper identifies Pangolin-CoV as a close relative of 2019-nCoV, showing high genomic similarity and key amino acid conservation in the S1 protein, suggesting it may be an intermediate host.
DOI 10.1101/2020.02.19.950253 - PathologybioRxiv
Are pangolins the intermediate host of the 2019 novel coronavirus (2019-nCoV) ?
P. Liu, J.-Z. Jiang, Y. Hua…·J. Chen
This study analyzes pangolin coronaviruses to assess their role as potential intermediate hosts of SARS-CoV-2, finding genetic relatedness but not direct origin.
DOI 10.1371/journal.ppat.1008421 - PathologybioRxivPreprint
Diastolic Dysfunction Accompanies Alterations in Myocardial Structure, Cellular Composition and Macrophage Polarization in Survivors of Ionizing Radiation Exposure
K. T. Michalson, G. O. Dugan, D. L. Caudell…·T. C. Register
This study examines cardiac effects of total body irradiation in rhesus macaques, finding diastolic dysfunction linked to structural changes and macrophage polarization.
DOI 10.1101/2020.02.18.953190