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This paper introduces a Drosophila model of renal fibrosis induced by steroids, showing that aldosterone and ecdysone trigger excess extracellular matrix formation through a G-protein coupled receptor, not the canonical nuclear receptor.

This study examines tannin and saponin degradation during co-composting of Camellia oleifera shell and seed cake, finding that higher seed cake proportions increase degradation rates but reduce C/N ratio and tannin content.

This paper develops a deep learning pipeline to automate HER2 gene amplification detection in FISH images, achieving accuracy comparable to pathologists.

This study compares VEGF expression in goats under continuous vs. intermittent systolic overload, finding greater VEGF upregulation in the intermittent group.

This study develops a 3-week dietary mouse model of NASH and shows liraglutide reduces hepatic steatosis and inflammation.

The paper shows that mice lacking HRG1 accumulate excess heme in macrophages, which they tolerate by forming hemozoin, a process previously only observed in blood-feeding parasites.

This paper introduces a simplified CNN architecture for efficient pan-cancer whole-slide image classification and outlier detection.

KPHMMER is a tool that identifies KEGG pathway-specific Pfam domains in user-defined organisms, improving detection accuracy and reducing computational cost.

The paper characterizes morphogenetic diversity of Rhizoctonia solani isolates from sugar beet and dry beans over 10 years using morphology and ISSR markers, finding crop-specific and broad-pathogenicity groups with no geographical correlation.

The paper validates a capillary electrophoresis assay for canine hemoglobin fractions and establishes reference intervals, finding no effect of age, sex, or anemia on hemoglobin composition.

This study develops a mouse model of light chain deposition disease, showing that pathogenic light chains cause glomerulosclerosis and kidney failure, and identifies potential therapeutic targets.

This paper evaluates the combination of artesunate and tetramethylpyrazine for treating experimental cerebral malaria, finding improved survival and neurological protection through proteomic analysis.

This study characterizes the parasitic effect of Phanerochaete chrysosporium strain B-22 on Meloidogyne incognita life stages and demonstrates its efficacy as a biocontrol agent for tomato plants.

This study examines if diet-induced obesity and diabetes in mice affect RANKL/RANK/OPG system and MMP expression in the kidney, finding no changes in protein expression despite histopathological changes.

The study examines how immunosuppressed mice control oral infection by Encephalitozoon intestinalis, finding increased T-cell populations and pro-inflammatory cytokines reduce infection.

This study shows that short-term fructose feeding in mice causes fat redistribution, BAT-to-visceral fat proportion changes, and BAT remodeling with enlarged lipid droplets, before metabolic dysfunction.

This study investigates whether prior dengue or Zika virus infection affects the severity of subsequent heterologous secondary infections in macaques, finding no significant impact on clinical outcomes.

This study shows that APOL1-G0 protects podocytes from HIV-induced damage in mice, while APOL1-G2 does not provide similar protection.

This study uses RNA-seq to analyze gene expression in podocytes, mesangial cells, and endothelial cells of a bigenic FSGS mouse model, identifying upregulated pathways and genes associated with fibrosis and disease progression.

The paper quantifies giant telomeric nuclear bodies (GT-NBs) in ALT cancer cells and shows they form by aggregating telomeres and associate with PML-NBs.