Author

E. E. Graves

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. Rafat· 3 shared A. C. Koong· 2 shared R. von Eyben· 2 shared A. Easton· 1 shared A. El Kaffas· 1 shared A. J. Giaccia· 1 shared A. Kim· 1 shared A. L. Bayer· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCancer Biology

M. Rafat

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A Novel Therapeutic Approach using CXCR3 Blockade to Treat Immune Checkpoint Inhibitor-mediated Myocarditis

Y. V. Huang, D. Lee, Y. Sun, H. Chou, B. Xu, Z. Lin, C. Branche, A. L. Bayer, S. Waliany, J. Neal, H. Wakelee, R. Witteles, P. Nguyen, E. E. Graves, P. Alcaide, , H. Zhu

This study identifies CXCR3-CXCL9/10 axis as a therapeutic target for ICI-mediated myocarditis using mouse models and human patient data.

bioRxiv · Jan 30, 2024 · PreprintCell Biology

Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironments

C. Beach, D. MacLean, D. Majorova, S. Melemenidis, D. K. Nambiar, R. K. Kim, G. N. Valbuena, S. Guglietta, C. Krieg, M. D. Damavandi, T. Suwa, A. Easton, E. Domingo, E. J. Moon, D. Jiang, , M. M. Olcina

This study identifies C5aR1 as a targetable receptor on cancer cells that enhances radiotherapy efficacy in immunosuppressive tumours by promoting apoptosis without affecting normal tissues.

bioRxiv · Jan 10, 2023 · PreprintCancer Biology

Non-Invasive monitoring of normal tissue radiation damage using quantitative ultrasound spectroscopy

M. Rafat, A. El Kaffas, A. Swarnakar, A. Shostak, E. E. Graves

This study uses quantitative ultrasound spectroscopy to monitor radiation-induced changes in normal tissue and correlates findings with histological features.

bioRxiv · May 10, 2022Cancer Biology

FLASH irradiation enhances the therapeutic index of abdominal radiotherapy for the treatment of ovarian cancer

K. Levy, S. Natarajan, J. Wang, S. Chow, J. T. Eggold, P. Loo, R. Manjappa, F. M. Lartey, E. Schüler, L. Skinner, M. Rafat, R. Ko, A. Kim, D. Al Rawi, R. von Eyben, , E. B. Rankin

This study shows FLASH irradiation reduces intestinal injury while maintaining ovarian cancer treatment efficacy in preclinical models.

bioRxiv · Dec 12, 2019 · PreprintCancer Biology

Extracellular 2’3’-cGAMP is an immunotransmitter produced by cancer cells and regulated by ENPP1

J. A. Carozza, V. Boehnert, K. C. Nguyen, G. Skariah, K. E. Shaw, J. A. Brown, M. Rafat, R. von Eyben, E. E. Graves, J. S. Glenn, M. Smith, L. Li

The paper identifies extracellular 2’3’-cGAMP as an immunotransmitter released by cancer cells, regulated by ENPP1, and shows its therapeutic potential in tumor treatment.

bioRxiv · Oct 7, 2019Biochemistry