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9 papers
Recent·Most cited
C. E. Bowman, M. D. Neinast, C. Jang, J. Patel, M. C. Blair, E. T. Mirek, W. O. Jonsson, Q. Chu, L. Merlo, L. Mandik-Nayak, T. G. Anthony, J. D. Rabinowitz, Z. Arany
This study shows that BT2, an inhibitor of BCKDK, reduces plasma tryptophan by displacing it from albumin, revealing an off-target effect on tryptophan metabolism.
bioRxiv · Mar 5, 2024Pharmacology & Toxicology
Z. Huo, Y. Duan, D. Zhan, X. Xu, N. Zheng, J. Cai, R. Sun, J. Wang, F. Cheng, Z. Gao, C. Xu, W. Liu, Y. Dong, S. Ma, Q. Zhang, , Y. Wang
This study uses proteomic profiling to stratify small cell lung cancer into three subtypes with distinct clinical outcomes and treatment responses, identifying potential therapeutic targets and improving prognosis prediction.
bioRxiv · Oct 22, 2023 · PreprintCancer Biology
R. Wang, Q. Chu, G. Meng, C. Li
This study reports the complete chloroplast genome of Akebia trifoliata and performs a comparative analysis within the Ranales clade, revealing its genetic structure and phylogenetic relationships.
bioRxiv · Jan 18, 2023 · PreprintPlant Biology
Q. Chu, T. Hakoyama, M. Hayashi, K. Toyooka, M. Sato, T. Kamiya, T. Fujiwara
The paper identifies SEN1 as a molybdate transporter responsible for exporting molybdate from host plant cytosol to symbiosomes for nitrogen fixation in Lotus japonicus.
bioRxiv · Nov 10, 2022 · PreprintPlant Biology
K. Chellappa, M. R. McReynolds, W. Lu, X. Zeng, M. Makarov, F. Hayat, S. Mukherjee, Y. R. Bhat, S. R. Lingala, R. T. Shima, H. C. Descamps, T. Cox, L. Ji, C. Jankowski, Q. Chu, , J. A. Baur
The paper shows NAD precursors cycle between host tissues and the gut microbiome to maintain NAD homeostasis.
bioRxiv · Nov 15, 2021Physiology
S. A. Wander, O. Cohen, X. Gong, G. N. Johnson, J. Buendia-Buendia, M. R. Lloyd, D. Kim, F. Luo, P. Mao, K. Helvie, K. J. Kowalski, U. Nayar, A. G. Waks, S. Parsons, R. Martinez, , N. Wagle
The paper identifies eight resistance mechanisms to CDK4/6 inhibitors in HR+ breast cancer, present in 80% of resistant tumors, with potential therapeutic strategies.
bioRxiv · Nov 28, 2019Cancer Biology
J. S. Araujo, R. M. P. Silva-Junior, T. Zhang, C. R. Schiavon, Q. Chu, M. Wu, C. L. S. Pontes, A. O. Souza, L. C. Alberici, A. M. Santos, S. B. Ingle, A. Saghatelian, J. Spudich, U. Manor, E. M. Espreafico
This paper shows myosin-Va facilitates mitochondrial fission in melanoma cells by interacting with Spire1C and localizing to fission sites, linking it to the Warburg effect.
bioRxiv · May 31, 2019 · PreprintCell Biology
Y. Wang, C. Bai, Y. Ruan, M. Liu, Q. Chu, L. Qiu, C. Yang, B. Li
The paper identifies a hypoxia-specific metabolic pathway in cancer cells that redirects glutamine nitrogen to secretory dihydroorotate, avoiding ammonia toxicity and supporting tumor growth.
bioRxiv · Jul 20, 2018Biochemistry