B. Bennett

Cryo-EM captures the coordination of long-range allostery and asymmetric electron transfer by a bi-copper cluster in the nitrogenase-like DPOR complex

The paper uses Cryo-EM to reveal how asymmetry and allostery coordinate long-range electron transfer in the DPOR enzyme through a bi-copper cluster.

ERα mediated gene state switching regulates the extent of the single-cell estrogen response

The paper investigates how altered ERα function and cofactor recruitment affect transcriptional bursting in estrogen responsive genes, finding gene-specific reductions in active alleles in BPA-treated cells.

Genetic Screen Identified Prmt5 as a Neuroprotection Target against Cerebral Ischemia

This study identifies Prmt5 as a negative regulator of neuronal survival during cerebral ischemia and shows that its inhibition protects against neuronal death in a mouse model.

HbtR, a heterofunctional homolog of the virulence regulator TcpP, facilitates the transition between symbiotic and planktonic lifestyles in Vibrio fischeri

This paper identifies HbtR, a TcpP homolog in Vibrio fischeri, which regulates the transition from symbiotic to planktonic lifestyles by modulating LitR activity and gene expression.

The flexible N-terminus of BchL protects its cluster in oxygenic environments and autoinhibits activity

This paper identifies a mechanism in BchL that protects its [4Fe-4S] cluster and autoinhibits activity, with ATP binding relieving inhibition and enabling complex formation with BchNB.

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide are Potent TMEM16A Antagonists that Fully Bronchodilate Airways

This paper identifies niclosamide and nitazoxanide as potent TMEM16A antagonists that fully bronchodilate airways, offering new treatment options for severe asthma and COPD.