B. O'Rourke

This study shows that SARS-CoV-2 infection causes persistent cardiac conduction system dysfunction in hamsters, driven by innate immune activation and mitochondrial ROS, with potential implications for long COVID.

This study investigates how cardiac sympathetic denervation prevents sudden cardiac arrest and improves cardiac function by enhancing mitochondrial-antioxidant capacity in a pressure-overload heart failure model.

This study shows PDE9 inhibition activates PPARa to enhance mitochondrial fat metabolism and reduce cardiometabolic syndrome in mice, with potential for treating obesity in men and postmenopausal women.

This study shows that using a bioreactor to isolate mesenchymal stromal cells (MSCs) delays clot formation compared to free MSCs, suggesting improved safety for systemic administration.

This paper introduces MitoWave, a tool to analyze mitochondrial membrane potential fluctuations during ischemia-reperfusion, showing significant differences in oscillatory behavior and correlations between frequency and cluster area.

This paper develops an optogenetic method to control mitochondrial membrane potential and shows its effects on cell fate, finding that light-induced depolarization can induce apoptosis or cytoprotection depending on duration and intensity.