M. McGrath

Deep spatial-omics to aid personalization of precision medicine in metastatic recurrent Head & Neck Cancers

This study uses spatial-omics to identify tumor metabolic states and immune cell profiles in OPSCC, leading to insights on ICI failure and potential drug targets.

Diet Induced Obesity and Diabetes Enhance Mortality and Reduces Vaccine Efficacy for SARS-CoV-2

This study shows that obesity and diabetes increase SARS-CoV-2 mortality and reduce vaccine efficacy in mice, with neutrophil depletion improving outcomes.

A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8

This study establishes a neonatal mouse model to study SARS-CoV-2 transmissibility, showing variant differences in infectious shedding and identifying ORF8's role in transmission.

SARS-CoV-2 Variant Spike and accessory gene mutations alter pathogenesis

This study investigates how non-Spike mutations in SARS-CoV-2 variants affect pathogenesis and transmission, revealing that accessory gene mutations can lead to attenuating phenotypes.

Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity

This paper introduces self-assembling short duplex RNAs that induce interferon production and inhibit multiple respiratory viruses.

Spatial structure affects evolutionary dynamics and drives genomic diversity in experimental populations of Pseudomonas fluorescens

This study shows that spatial structure in Pseudomonas fluorescens populations slows adaptation, preserves dispersal ability, and increases genomic diversity, but not parallel evolution.

Immunogenicity and In vivo protection of a variant nanoparticle vaccine that confers broad protection against emerging SARS-CoV-2 variants

This study evaluates a nanoparticle vaccine against SARS-CoV-2 variants, showing it induces strong immune responses and protection in mice and baboons against multiple variants.

Collaboration between the Fab and Fc contribute to maximal protection against SARS-CoV-2 in nonhuman primates following NVX-CoV2373 subunit vaccine with Matrix-M™ vaccination

This study shows that NVX-CoV2373 vaccine induces antibodies with both neutralizing and Fc-effector functions, which together provide maximal protection against SARS-CoV-2 in non-human primates.

Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail

This paper determines the structures of two antibodies in the AZD7442 cocktail that neutralize SARS-CoV-2 and identifies critical residues for neutralization and viral escape.

Human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics

This paper demonstrates the use of human organ chips to rapidly repurpose therapeutics for viral pandemics, identifying amodiaquine as a potential treatment for SARS-CoV-2.

Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow

The paper identifies discrete populations of isotype-switched memory B cells in murine spleen and bone marrow, with distinct locations and characteristics.