W. Fu

TNFR1-mediated senescence and lack of TNFR2-signaling limit human intervertebral disc cell repair in back pain conditions

This study identifies TNFR1-mediated senescence and limited TNFR2 signaling as barriers to intervertebral disc cell repair in back pain, suggesting immunomodulation as a therapeutic strategy.

Neurotensin-Neurotensin Receptor 2 signaling in adipocytes regulates food intake through ceramide metabolism

This study shows that NTS-NTSR2 signaling in white adipocytes regulates food intake by modulating ceramide metabolism and GDF15 production.

Zero-shot learning enables instant denoising and super-resolution in optical fluorescence microscopy

This paper introduces a zero-shot deep learning method for super-resolution microscopy that enhances resolution with less fluorescence and no training data.

Gaudichaudione H inhibits Herpes Simplex Virus-1 replication by regulating cellular nuclear factor-κB in an interferon-γ-independent manner

This paper identifies Gaudichaudione H as an antiviral compound that inhibits HSV-1 replication by suppressing NF-κB activation without requiring interferon-γ.

Structure-Kinetic Relationship for Drug Design Revealed by PLS Model with Retrosynthesis-Based Pre-trained Molecular Representation and Molecular Dynamics Simulation

This paper develops a PLS model combining retrosynthesis-based molecular representations and MD simulations to predict koff values for HSP90 inhibitors, showing high correlation with experimental data.

Organization, genomic targeting and assembly of three distinct SWI/SNF chromatin remodeling complexes in Arabidopsis

RGA1 alleviates low-light-repressed pollen tube growth by improving the metabolism and allocation of sugars and energy

This study shows RGA1 improves pollen tube growth under low-light by enhancing sugar and energy metabolism in rice pistils.

Characterizations of enhanced infectivity and antibody evasion of Omicron BA.2.75

This study characterizes the enhanced infectivity and antibody evasion properties of the SARS-CoV-2 Omicron subvariant BA.2.75 compared to BA.5 and other variants.

Structural characterization of human RPA70N association with DNA damage response proteins

This study presents high-resolution crystal structures of RPA70N in complex with peptides from multiple DNA damage response proteins, revealing diverse binding modes beyond ssDNA mimicry.

Plasmacytoid dendritic cells regulate megakaryocyte and platelet homeostasis

This study identifies plasmacytoid dendritic cells (pDCs) as regulators of megakaryopoiesis and platelet homeostasis, showing their role in maintaining steady-state and stress conditions, and their involvement in SARS-CoV2-induced thrombosis.

A novel intranasal administration adenoviral vector-based platform for rapid COVID-19 vaccine development

This paper develops a chimpanzee adenovirus-based vaccine against the SARS-CoV-2 Delta variant and shows it induces strong immunity and protects mice from challenge.

Structural and functional characterizations of altered infectivity and immune evasion of SARS-CoV-2 Omicron variant

The paper characterizes structural and functional changes in the SARS-CoV-2 Omicron variant's Spike protein, identifying new immune escape sites and providing insights for vaccine development.

A subset of Memory B-derived antibody repertoire from 3-dose vaccinees is ultrapotent against diverse and highly transmissible SARS-CoV-2 variants, including Omicron

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

In vitro validation of neoantigen prediction algorithm for developing personalized cancer vaccine therapy

The paper validates a neoantigen prediction algorithm, Neopepsee, by testing its immunogenicity using ELISpot assays on patient-derived samples and compares it to pVACseq.

The possible fidelity-speed-proofreading cost trade-offs in DNA replication due to the exonuclease proofreading

This paper re-examines fidelity-speed and fidelity-proofreading cost trade-offs in DNA replication under the exonuclease-proofreading mechanism using a first-passage method.

Furfural residues as soil amendments for long-term seed corn production: effects on community composition and diversity of rhizosphere microbiota

This study examines how furfural residue amendments affect rhizosphere microbiota diversity and composition in long-term maize monocropping, showing increased beneficial microbes and reduced pathogens.

TIGIT-Fc Promotes Antitumour Immunity

This study shows that TIGIT-Fc promotes antitumour immunity by enhancing CD8+ T and NK cell effector functions and inducing Th1 development, suggesting its potential as a therapeutic strategy.

Architecture of the Tuberous Sclerosis Protein Complex

This study uses cryo-EM to determine the structure of the TSCC complex, revealing its architecture and potential mechanisms of Rheb regulation.

Synthetic Cellular Immunity based on CAR repertoire for Human Immunotherapy

This paper demonstrates that engineered T cell libraries with CAR constructs can recognize nonself-antigens, expand clonally, persist, and show immunologic memory against tumors in murine models.

CAR Macrophages for SARS-CoV-2 Immunotherapy

This study genetically modifies human macrophages with CARs to target SARS-CoV-2, showing that CARMERTK macrophages reduce viral load without increasing proinflammatory cytokines.

A novel biparatopic antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy

The paper develops a biparatopic antibody-ACE2 fusion (89C8-ACE2) that effectively blocks SARS-CoV-2 infection in vitro and neutralizes authentic virus at low nanomolar concentrations.

Influence of isolation by environment and landscape heterogeneity on genetic structure of wild rice Zizania latifolia along a latitudinal gradient

This study examines how environmental factors and landscape heterogeneity influence genetic structure in wild rice Zizania latifolia across a latitudinal gradient in China.

Tracing the origin of a new organ by inferring the genetic basis of rumen evolution

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

Potent neutralization of 2019 novel coronavirus by recombinant ACE2-Ig

This study develops a recombinant ACE2-Ig fusion protein that neutralizes both SARS-CoV and 2019-nCoV in vitro, showing cross-reactivity and potential for diagnostic, prophylactic, and therapeutic applications.

TIGIT-Fc Promote Immune Tolerance at the Feto-maternal Interface

The paper shows TIGIT-Fc promotes immune tolerance at the feto-maternal interface by enhancing IL-10 production and TH2 polarization in decidual CD4+ T cells, and increasing pregnancy rates in stressed mice.

Treatment of Murine Lupus with TIGIT-Ig

This study shows that TIGIT-Ig treatment delays lupus onset, reduces autoantibodies, and improves survival in mice, suggesting potential for human autoimmune disease therapy.

Targeting RyR2 with a phosphorylation site-specific nanobody Reverses Dysfunction of Failing Cardiomyocytes in Rat

This study shows that delivering a RyR2-targeting nanobody via AAV9 improves cardiac function in rat models of ischemic heart failure by reducing calcium leak and reversing dysfunction.

Senkyunolide A Protects Corticosterone-Induced Cell Apoptosis Via Modulating Protein Phosphatase 2A And α-Synuclein

This study identifies senkyunolide A as a neuroprotective compound that mitigates corticosterone-induced cell apoptosis by modulating PP2A and α-synuclein levels in PC12 cells.