B. Garcia

An optimized and robust workflow for quantifying the canonical histone ubiquitination marks H2AK119ub and H2BK120ub by LC-MS/MS

The paper develops a robust LC-MS/MS workflow for quantifying H2AK119ub and H2BK120ub histone ubiquitination marks, improving upon existing methods for C-terminal modifications.

Harnessing molecular mechanism for precision medicine in dilated cardiomyopathy caused by a mutation in troponin T

This study connects genotype, phenotype, and drug response in dilated cardiomyopathy using molecular mechanism-based computational and experimental approaches for a troponin T mutation.

SIRT7 regulates NUCKS1 chromatin binding to elicit metabolic and inflammatory gene expression in senescence and liver aging

This study identifies NUCKS1 as a novel SIRT7 interactor that promotes chromatin binding during senescence and liver aging, leading to metabolic and inflammatory gene expression.

Electrostatic encoding of genome organization principles within single native nucleosomes

This study shows that single nucleosomes encode A/B compartment information through biophysical properties, specifically condensability, which correlates with gene expression and is electrostatic in nature.

Signal Improved ultra-Fast Light-sheet Microscope (SIFT) for large tissue imaging

The paper introduces an improved light-sheet microscope that increases imaging speed and signal strength for large tissue samples.

TGFβ controls alveolar type 1 epithelial cell plasticity and alveolar matrisome gene transcription

This study shows TGFβ signaling is essential for maintaining alveolar type 1 cell fate and regulates the alveolar matrisome through integrin transcription and mechanotransduction.

Peripheral detection of viruses shapes brain immunity and behavior in zebrafish

This study shows that viral detection by olfactory sensory neurons in zebrafish triggers neuroimmune responses and behavioral changes through PACAP signaling in the olfactory bulb.

Antibody landscape of C57BL/6 mice cured of B78 melanoma via immunotherapy

The paper identifies antibodies targeting melanoma peptides in C57BL/6 mice cured of B78 melanoma via immunotherapy, using proteome arrays and ELISA validation.

Harnessing the Intrinsic Photochemistry of Isoxazoles for the Development of Chemoproteomic Crosslinking Methods

This paper introduces a new photo-crosslinking method using isoxazole's intrinsic photochemistry, validated across multiple proteins in vitro and ex vivo.

Poly (acetyl arginyl) glucosamine attenuates Pseudomonas aeruginosa in a rat lung infection model

This study evaluates PAAG's effect on P. aeruginosa biofilms and lung infections in rats, finding it reduces bacterial biomass and inflammation.

A dynamic and combinatorial histone code drives malaria parasite asexual and sexual development

This study identifies novel histone PTMs and their combinatorial interactions in Plasmodium falciparum, revealing their role in regulating gene expression during asexual and sexual development.

Structural and mechanistic insight into CRISPR-Cas9 inhibition by anti-CRISPR protein AcrIIC4

This study investigates how AcrIIC4 inhibits CRISPR-Cas9 by binding to its Recognition Domain and blocking DNA cleavage through conformational changes.

Listeria phages induce Cas9 degradation to protect lysogenic genomes

This study identifies AcrIIA1 as a phage-encoded protein that inhibits Cas9 in Listeria monocytogenes by promoting its degradation, protecting lysogenic genomes.

Histone methyltransferase MMSET/NSD2 is essential for generation of B1 cell compartment in mice

This study identifies MMSET/NSD2 as essential for B1 cell development in mice, showing its role in histone methylation and B cell lineage specification.

Myeloid Lineage Enhancers Drive Oncogene Synergy in CEBPA/CSF3R Mutant Acute Myeloid Leukemia

The paper identifies mutation synergy between CSF3R and CEBPA in AML, showing their interaction at myeloid lineage enhancers and the requirement of CEBPA mutations as an initial event.