R. Zhu

This study uses chiral quantum dots to investigate origin-dependent exosome uptake and cargo release mechanisms in different recipient cells.

The paper shows CAM-A modulators eliminate HBV-infected hepatocytes with high core antigen levels via apoptosis, dependent on de novo core protein translation.

The paper identifies host-microbiota interactions in colorectal cancer subtypes, revealing distinct gene-microbe associations that contribute to tumor microenvironment heterogeneity.

This study shows that left-handed graphene quantum dots (L-GQDs) have higher diffusion and drug delivery efficacy in tumor-like spheroids compared to right-handed D-GQDs.

This paper deletes the I196L gene from ASFV SY18, resulting in a less virulent recombinant virus that protects pigs against ASFV challenge.

This study identifies Sp1 as a regulator of ACE2 expression in response to SARS-CoV-2 infection and shows that targeting Sp1 reduces viral replication and tissue injury in Syrian hamsters.

This study identifies microbial single nucleotide variants (SNVs) as superior biomarkers for early detection of colorectal cancer, outperforming species-level signatures in multiple validation cohorts.

This study shows TERT promotes thyroid cancer dedifferentiation and progression by enhancing ribosome biogenesis, and inhibiting rRNA synthesis can reverse this process.

This paper presents a chiral graphene quantum dots platform for efficient drug loading into exosomes, achieving high loading efficiencies for both hydrophobic and hydrophilic drugs.

This study shows engineered graphene quantum dots inhibit and disassemble tau protein aggregates in vitro, suggesting their potential as a treatment for tauopathies.

This study identifies specific HA mutations in H9N2 avian influenza virus that influence antigenic variation and immune escape from vaccine antibodies.

This study identifies unbalanced dietary patterns as contributors to precocious puberty by altering gut microbiota and host metabolites, with biomarkers showing high diagnostic accuracy.

This study shows that helical pitch size determines microtubule plus end dynamic instability through stochastic simulations, finding that 1.5 dimer pitch optimizes growth and shrinkage phases.

The paper identifies microbial markers for early colorectal cancer detection across populations using meta-analysis and classifier models, achieving high diagnostic accuracy.

The paper identifies bile acid metabolizing microbes and genes associated with NAFLD subtypes using metagenomic data and develops a classifier model for NAFLD detection.

This study analyzes Woesearchaeota distribution and diversity using 16S rRNA and metagenomic data, revealing their presence in host-associated environments and genomic variation across ecosystems.

This study shows that background speech and white noise improve visual working memory by increasing arousal, as measured by physiological signals.

This study identifies a conserved exZZU extension in ankyrins that enhances binding to beta-spectrins through structural interactions, but shows that direct binding does not determine pairing specificity.

This study identifies an insertion sequence in SARS-CoV-2 spike protein that enhances cleavage efficiency and expands tissue tropism beyond the lungs.

This paper proposes a strategy to select crop varieties based on yield factors and meteorological predictions, showing 70% and 50% success rates in two pilot regions for soybean variety selection.

The paper uses integrated proteomic and metabolic single-cell assays to identify two distinct adaptive pathways in BRAF-mutant melanoma cells during drug treatment.

The paper shows that Asgard and CPR metagenome assembled genomes (MAGs) fail to meet basic phylogenetic criteria due to their anomalous ribosomal protein evolutionary histories, suggesting they are binning artifacts.

The paper investigates the phylogenetic placement of mitochondria within Alphaproteobacteria using alternative methods to address compositional heterogeneity.

This study demonstrates that large-particle fluorescence-activated cell sorting (LP-FACS) improves the isolation of viable adult cardiomyocytes, enabling high-quality single-cell RNA sequencing and functional analysis.

This study identifies EZH2 as a p53 mRNA-binding protein that enhances translation of gain-of-function p53 mutants, promoting cancer growth and metastasis, and shows that inhibiting EZH2 causes synthetic lethality in these cells.