N. Lin

An Open-Source Membrane Stretcher for Simultaneous Mechanical and Structural Characterizations of Soft Materials and Biological Tissues

This paper introduces an open-source stretching system for simultaneous mechanical and structural analysis of soft materials and biological tissues.

Image-based Strain Analysis Reveals Intracellular Strain Controlled by Nucleo-Cytoskeletal Coupling

This study measures intracellular strain using microscopy and finds an inverse relationship between cytoplasmic and nuclear strains controlled by nucleo-cytoskeletal coupling.

Regulation of Chromatin Modifications through Coordination ofNucleus Size and Epithelial Cell Morphology Heterogeneity

The paper shows that cell morphology and nucleus size heterogeneity drive chromatin modification changes, affecting euchromatic and heterochromatic marks.

Microwell-Based Flow Culture Increases Viability and Restores Drug Response in Prostate Cancer Spheroids

This study introduces a Microwell Flow Device that improves spheroid viability and drug response in prostate cancer models by reducing hypoxia-related necrosis.

Benzo(a)pyrene regulates chaperone-mediated autophagy via heat shock protein 90

This study shows that benzo(a)pyrene induces chaperone-mediated autophagy (CMA) and DNA damage through heat shock protein 90 (HSP90) in lung cells.

Phylogenomic analyses using genomes and transcriptomes do not resolve relationships among major clades in Phrymaceae

This study uses genome and transcriptome data to analyze phylogenetic relationships in Phrymaceae, finding that major clades remain unresolved despite large-scale data.

Intragenic proviral elements support transcription of defective HIV-1 proviruses

The paper shows defective HIV-1 proviruses can be transcribed via intragenic elements, producing aberrant RNAs that may contribute to inflammation in HIV-positive individuals.

Insights into the drivers of radiating diversification in biodiversity hotspots using Saussurea (Asteraceae) as a case

This study examines factors driving radiating diversification in Saussurea using Miocene to present data, finding increased diversification rates linked to climate fluctuations and adaptive traits.

Mechano-bactericidal nanopillars require external forces to effectively kill bacteria

This study shows that nanopillar surfaces require external forces to kill bacteria, challenging the idea that nanopillars alone are effective antibacterial agents.

CRISPR-Assisted DNA Detection, a novel dCas9-based DNA detection technique

This paper develops a CRISPR-based DNA detection method (CADD) that rapidly and specifically detects DNA from bacteria, cancer cells, and viruses in 30 minutes at room temperature.

Gene interfered-ferroptosis therapy of cancer

This paper develops a novel cancer therapy called gene interfered-ferroptosis therapy (GIFT) that selectively induces ferroptosis in cancer cells while sparing normal cells.

Plastome phylogenomic study of Gentianeae (Gentianaceae): widespread gene tree discordance and its association with evolutionary rate heterogeneity of plastid genes

This study analyzes plastome sequences from Gentianeae to show gene tree discordance and evolutionary rate heterogeneity among plastid genes, suggesting the need for more nuanced phylogenomic approaches.

HIV-1 co-receptor usage and variable loop contact impacts V3 loop bnAb susceptibility

The paper develops a sequence-based algorithm to predict HIV-1 receptor usage and bnAb susceptibility, showing that CXCR4-using strains are less susceptible to V3 loop bnAbs due to structural interactions.

Multivariate Computational Analysis of Gamma Delta T cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging

This study identifies divergent inflammatory signatures in ART-suppressed HIV+ individuals compared to uninfected controls using multivariate analysis of immune receptor and plasma marker data.

DNA methylation signature of smoking in lung cancer is enriched for exposure signatures in newborn and adult blood.

The paper identifies DNA methylation signatures of smoking in lung cancer and finds significant overlap with signatures in newborn and adult blood.