M. Lampson

The genomic landscape, causes, and consequences of extensive phylogenomic discordance in Old World mice and rats

This study investigates phylogenomic discordance in Old World mice and rats, finding that genetic linkage and selection influence phylogenetic patterns and that assuming a single species tree can lead to errors in detecting positive selection.

Confinement with Myosin-II suppression increases heritable loss of chromosomes, using live-cell ChReporters

The paper uses live-cell ChReporters to show that Myosin-II suppression in confined mitosis increases heritable chromosome loss, independent of spindle assembly checkpoint in 3D and 2D.

Separase cleaves the kinetochore protein Meikin to direct the meiosis I/II transition

This study shows that Separase cleaves Meikin to control the meiosis I/II transition by altering its function and promoting Rec8 cleavage.

Centromere drive and suppression by parallel pathways for recruiting microtubule destabilizers

The paper shows that centromere drive is suppressed by two parallel pathways, with heterochromatin and kinetochore pathways differing in their suppression of selfish DNA effects.

Tension promotes kinetochore-microtubule release in response to Aurora B activity

The paper shows that Aurora B kinase activity leads to kinetochore-microtubule release under high tension and depolymerization under low tension, suggesting tension-dependent error correction mechanisms.

Molecular and evolutionary strategies of meiotic cheating by selfish centromeres

The paper investigates how selfish centromeres evolve to bias transmission during meiosis by altering histone phosphorylation and microtubule dynamics, and shows that centromere drive depends on slowing meiotic progression.