Structural basis of bile acid receptor activation and Gs coupling
F. Yang, C. Mao, L. Guo, J. Lin, Q. Ming, P. Xiao, X. Wu, Q. Shen, S. Guo, D.-D. Shen, R. Lu, L. Zhang, S. Huang, Y. Ping, C. Zhang, , Y. Zhang
The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.
bioRxiv · May 24, 2020 · PreprintBiochemistry