F. Yi

CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit

This study identifies FASLG expression patterns and shows that FAS-L/FAS auto-regulation governs CAR-T and CAR-NK cell persistence, enhancing antitumor efficacy when FAS is inhibited.

A force-sensitive adhesion GPCR is indispensable in normal equilibrioception

This study identifies LPHN2/ADGRL2 as a force-sensitive adhesion GPCR essential for normal equilibrioception by regulating mechanoelectrical transduction in utricular hair cells.

Force sensing GPR133 is essential for normal balance and modulates vestibular hair cell membrane excitability via Gi signaling and CNGA3 coupling

This study identifies GPR133 as a force-sensing GPCR essential for balance, showing it modulates vestibular hair cell excitability via Gi signaling and CNGA3 coupling.

The resting and ligand-bound states of the membrane-embedded human T-cell receptor-CD3 complex

This study presents cryo-EM structures of the human TCR-CD3 complex in its resting and ligand-bound states, revealing conformational changes and the importance of native lipid environments.

MG53 slows neuromuscular junction loss and prolongs survival in ALS

This study shows that MG53 reduces neuromuscular junction loss and extends survival in ALS by protecting diaphragm muscle and NMJ integrity.

Structural basis of bile acid receptor activation and Gs coupling

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

Physical activity unveils the relationship between mitochondrial energetics, muscle quality and physical function in older adults

This study examines mitochondrial function in older adults with varying physical activity levels, finding that active older adults have mitochondrial capacity similar to younger active individuals, linked to better muscle quality and physical function.