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Lipidic and senescent macrophages predict progression and response to combinatorial immunotherapy in triple-negative breast cancer

SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids

This study shows SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids, upregulating interferon signaling linked to cytokine release syndrome.

Sterol 3-beta-Glucosyltransferase TRANSPARENT TESTA15 Controls Seed Development and Flavanol Accumulation through its Role in Vacuole Biogenesis and Maintenance in Arabidopsis

This study shows that TT15 controls seed development and flavanol accumulation by modulating vacuole biogenesis and maintenance in Arabidopsis.

Modular Pooled Discovery of Synthetic Knockin Sequences to Program Durable Cell Therapies

The paper develops ModPoKI, a platform for modular construction of DNA knockin libraries to identify gene constructs that enhance T cell function and persistence.

Protein Vaccine Induces a Durable, More Broadly Neutralizing Antibody Response in Macaques than Natural Infection with SARS-CoV-2 P.1

A recombinant subunit vaccine with CoVaccine HT adjuvant provides durable, broad neutralizing antibodies against SARS-CoV-2 VOCs in macaques, outperforming natural infection in protection and viral load reduction.

Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT adjuvant induce broad, Th1 biased, humoral and cellular immune responses in mice